ArticleMolecular and cellular biology2006
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Chromatin and Epigenetic Dysregulation of Prostate Cancer Development, Progression, and Therapeutic Response.Cancers · 2021Review
- Review
- Epigenetic Regulation in Prostate Cancer Progression.Current molecular biology reports · 2018Review
- Exploiting Epigenetic Alterations in Prostate Cancer.International journal of molecular sciences · 2017Review
- Src promotes castration-recurrent prostate cancer through androgen receptor-dependent canonical and non-canonical transcriptional signatures.Oncotarget · 2017Article
- Epigenomic Regulation of Androgen Receptor Signaling: Potential Role in Prostate Cancer Therapy.Cancers · 2017Review
- Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer.PloS one · 2017Article
- Putative functions of tissue kallikrein-related peptidases in vaginal fluid.Nature reviews. Urology · 2016Review
- Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration-resistant prostate cancer.Oncogene · 2016Article
- REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer.Nucleic acids research · 2014Article
- Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.PLoS genetics · 2013Article
- Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions.Nucleic acids research · 2012Article
- Genome-wide DNA methylation profiling of CpG islands in hypospadias.The Journal of urology · 2012Article
- The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor.Molecular and cellular endocrinology · 2012Article
- Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.Molecular and cellular biology · 2011Article
- Androgen receptor responsive enhancers are flanked by consistently-positioned H3-acetylated nucleosomes.Cell cycle (Georgetown, Tex.) · 2010Article
- Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles.Journal of cellular and molecular medicine · 2010Article
- Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer.Current drug targets · 2010Review
- A systematic approach to understand the functional consequences of non-protein coding risk regions.Cell cycle (Georgetown, Tex.) · 2010Article
- Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA.Molecular endocrinology (Baltimore, Md.) · 2009Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Prostate cancers (PCas) become resistant to hormone withdrawal through increased androgen receptor (AR) signaling. Here we show increased AR-mediated transcription efficiency in PCa cells that have acquired the ability to grow in low concentrations of androgen. Compared to androgen-dependent PCa cells, these cells showed increased activity of transiently transfected reporters and increased mRNA synthesis relative to levels of AR occupancy of the prostate-specific antigen (PSA) gene. The locus also displayed up to 10-fold-higher levels of histone H3-K9/K14 acetylation and H3-K4 methylation across the entire body of the gene. Although similar increased mRNA expression and locus-wide histone acetylation were also observed at another kallikrein locus (KLK2), at a third AR target locus (TMPRSS2) increased gene expression and locus-wide histone acetylation were not seen in the absence of ligand. Androgen-independent PCa cells have thus evolved three distinctive alterations in AR-mediated transcription. First, increased RNA polymerase initiation and processivity contributed to increased gene expression. Second, AR signaling was more sensitive to ligand. Third, locus-wide chromatin remodeling conducive to the increased gene expression in the absence of ligand was apparent and depended on sustained AR activity. Therefore, increased AR ligand sensitivity as well as locus-specific chromatin alterations contribute to basal gene expression of a subpopulation of specific AR target genes in androgen-independent PCa cells. These features contribute to the androgen-independent phenotype of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.