ArticleMolecular and cellular biology2006
Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 152 citations in OpenAlex.
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- Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity.Biochemical Society transactions · 2026Review
- DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models.Biomedicines · 2026Review
- Daphnia magna diapause-interrupted embryogenesis has changes in histone modifications at H3K9.Epigenetics & chromatin · 2026Article
- Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization.Investigative ophthalmology & visual science · 2025Article
- The role of noncoding RNAs in pancreatic birth defects.Birth defects research · 2023Review
- DNA methylation safeguards the generation of hematopoietic stem and progenitor cells by repression of Notch signaling.Development (Cambridge, England) · 2022Article
- Uncovering Regulators of Heterochromatin Mediated Silencing Using a Zebrafish Transgenic Reporter.Frontiers in cell and developmental biology · 2022Article
- Mapping epigenetic divergence in the massive radiation of Lake Malawi cichlid fishes.Nature communications · 2021Article
- Epigenetic regulation of retinal development.Epigenetics & chromatin · 2021Review
- Article
- Transgenerational inheritance of impaired larval T cell development in zebrafish.Nature communications · 2020Article
- Newly identified Gon4l/Udu-interacting proteins implicate novel functions.Scientific reports · 2020Article
- dnmt1 function is required to maintain retinal stem cells within the ciliary marginal zone of the zebrafish eye.Scientific reports · 2020Article
- Chromatin dynamics at the maternal to zygotic transition: recent advances from the zebrafish model.F1000Research · 2020Review
- Age-related macular degeneration (AMD) mitochondria modulate epigenetic mechanisms in retinal pigment epithelial cells.Experimental eye research · 2019Article
- Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development.Developmental biology · 2019Article
- Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation.Nature communications · 2019Article
- Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome.eLife · 2018Article
- Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.International journal of molecular sciences · 2018Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address this issue, we examined the roles of DNA methyltransferase 1 (Dnmt1) and the H3K9 histone methyltransferase Suv39h1 in zebra fish development. Knockdown of Dnmt1 in zebra fish embryos caused defects in terminal differentiation of the intestine, exocrine pancreas, and retina. Interestingly, not all tissues required Dnmt1, as differentiation of the liver and endocrine pancreas appeared normal. Proper differentiation depended on Dnmt1 catalytic activity, as Dnmt1 morphants could be rescued by active zebra fish or human DNMT1 but not by catalytically inactive derivatives. Dnmt1 morphants exhibited dramatic reductions of both genomic cytosine methylation and genome-wide H3K9 trimethyl levels, leading us to investigate the overlap of in vivo functions of Dnmt1 and Suv39h1. Embryos lacking Suv39h1 had organ-specific terminal differentiation defects that produced largely phenocopies of Dnmt1 morphants but retained wild-type levels of DNA methylation. Remarkably, suv39h1 overexpression rescued markers of terminal differentiation in Dnmt1 morphants. Our results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.