ArticleJournal of bacteriology2006
The atlA operon of Streptococcus mutans: role in autolysin maturation and cell surface biogenesis.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 82 citations in OpenAlex.
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- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Identification and genetic engineering of pneumococcal capsule-like polysaccharides in commensal oral streptococci.Microbiology spectrum · 2024Article
- Glucose Phosphotransferase System Modulates Pyruvate Metabolism, Bacterial Fitness, and Microbial Ecology in Oral Streptococci.Journal of bacteriology · 2023Article
- Activation of TnSmu1, an integrative and conjugative element, by an ImmR-like transcriptional regulator inMicrobiology (Reading, England) · 2022Article
- Spontaneous Mutants of Streptococcus sanguinis with Defects in the Glucose-Phosphotransferase System Show Enhanced Post-Exponential-Phase Fitness.Journal of bacteriology · 2021Article
- Modification of cell wall polysaccharide guides cell division in Streptococcus mutans.Nature chemical biology · 2021Article
- Undermodification cues division.Nature chemical biology · 2021Article
- A single system detects and protects the beneficial oral bacterium Streptococcus sp. A12 from a spectrum of antimicrobial peptides.Molecular microbiology · 2021Article
- Article
- Multiple factors are involved in regulation of extracellular membrane vesicle biogenesis in Streptococcus mutans.Molecular oral microbiology · 2021Article
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- Antibiotic and Antibiofilm Activities ofPathogens (Basel, Switzerland) · 2020Article
- The Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp onFrontiers in microbiology · 2020Article
- Novel Probiotic Mechanisms of the Oral BacteriumApplied and environmental microbiology · 2019Article
- Streptococcus mutans requires mature rhamnose-glucose polysaccharides for proper pathophysiology, morphogenesis and cellular division.Molecular microbiology · 2019Article
- Intracellular Signaling by themSphere · 2018Article
- Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans.AMB Express · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Smu0630 protein (AtlA) was recently shown to be involved in cell separation, biofilm formation, and autolysis. Here, transcriptional studies revealed that atlA is part of a multigene operon under the control of at least three promoters. The morphology and biofilm-forming capacity of a nonpolar altA mutant could be restored to that of the wild-type strain by adding purified AtlA protein to the medium. A series of truncated derivatives of AtlA revealed that full activity required the C terminus and repeat regions. AtlA was cell associated and readily extractable from with sodium dodecyl sulfate. Of particular interest, the surface protein profile of AtlA-deficient strains was dramatically altered compared to the wild-type strain, as was the nature of the association of the multifunctional adhesin P1 with the cell wall. In addition, AtlA-deficient strains failed to develop competence as effectively as the parental strain. Mutation of thmA, which can be cotranscribed with atlA and encodes a putative pore-forming protein, resulted in a phenotype very similar to that of the AtlA-deficient strain. ThmA was also shown to be required for efficient processing of AtlA to its mature form, and treatment of the thmA mutant strain with full-length AtlA protein did not restore normal cell separation and biofilm formation. The effects of mutating other genes in the operon on cell division, biofilm formation, or AtlA biogenesis were not as profound. This study reveals that AtlA is a surface-associated protein that plays a critical role in the network connecting cell surface biogenesis, biofilm formation, genetic competence, and autolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.