ArticleJournal of bacteriology2006
Loss of expression of cspC, a cold shock family gene, confers a gain of fitness in Escherichia coli K-12 strains.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Genomic diversification, adaptive convergence, and regulatory rewiring in aging Escherichia coli colonies.BMC microbiology · 2026Article
- Insights into the Phylogeny and Evolution of Cold Shock Proteins: From EnteropathogenicInternational journal of molecular sciences · 2019Article
- Inverted Regulation of Multidrug Efflux Pumps, Acid Resistance, and Porins in Benzoate-Evolved Escherichia coli K-12.Applied and environmental microbiology · 2019Article
- Adaptive laboratory evolution of a genome-reduced Escherichia coli.Nature communications · 2019Article
- High mutation rates limit evolutionary adaptation in Escherichia coli.PLoS genetics · 2018Article
- Systems-level understanding of ethanol-induced stresses and adaptation in E. coli.Scientific reports · 2017Article
- Comparative genomics of Clavibacter michiganensis subspecies, pathogens of important agricultural crops.PloS one · 2017Article
- Cold Shock Proteins: A Minireview with Special Emphasis on Csp-family of Enteropathogenic Yersinia.Frontiers in microbiology · 2016Review
- Model Uracil-Rich RNAs and Membrane Protein mRNAs Interact Specifically with Cold Shock Proteins in Escherichia coli.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CspA family of cold shock genes in Escherichia coli K-12 includes nine paralogs, cspA to cspI. Some of them have been implicated in cold stress adaptation. Screening for mutations among common laboratory E. coli strains showed a high degree of genetic diversity in cspC but not in cspA and cspE. This diversity in cspC was due to a wide spectrum of variations including insertions of IS elements, deletion, and point mutation. Northern analysis of these mutants showed loss of cspC expression in all but one case. Further analysis of the loss-of-function cspC mutants showed that they have a fitness advantage in broth culture after 24 h over their isogenic wild-type derivatives. Conversely, introduction of mutated cspC alleles conferred a competitive fitness advantage to AB1157, a commonly used laboratory strain. This provides the evidence that loss of cspC expression is both necessary and sufficient to confer a gain of fitness as seen in broth culture over 24 h. Together, these results ascribe a novel role in cellular growth at 37 degrees C for CspC, a member of the cold shock domain-containing protein family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.