ArticleBiophysical journal2006
Dynamic studies of scaffold-dependent mating pathway in yeast.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Phosphatase specificity and pathway insulation in signaling networks.Biophysical journal · 2015Article
- Enhancement of tunability of MAPK cascade due to coexistence of processive and distributive phosphorylation mechanisms.Biophysical journal · 2014Article
- Identification of the molecular mechanisms for cell-fate selection in budding yeast through mathematical modeling.Biophysical journal · 2013Article
- Quantitative measurement of protein relocalization in live cells.Biophysical journal · 2013Article
- Machines vs. ensembles: effective MAPK signaling through heterogeneous sets of protein complexes.PLoS computational biology · 2013Article
- Crosstalk and competition in signaling networks.Biophysical journal · 2012Article
- Computational modeling of cellular signaling processes embedded into dynamic spatial contexts.Nature methods · 2012Article
- How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches.Frontiers in physiology · 2012Article
- Dose-response aligned circuits in signaling systems.PloS one · 2012Article
- Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Integral control of plant gravitropism through the interplay of hormone signaling and gene regulation.Biophysical journal · 2011Article
- Article
- Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence.Molecular and cellular biology · 2009Article
- Pulsing cells: how fast is too fast?HFSP journal · 2008Article
- Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.Molecular systems biology · 2008Article
- Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mating pathway in Saccharomyces cerevisiae is one of the best understood signal transduction pathways in eukaryotes. It transmits the mating signal from plasma membrane into the nucleus through the G-protein coupled receptor and the mitogen-activated protein kinase (MAPK) cascade. According to current understanding of the mating pathway, we construct a system of ordinary differential equations to describe the process. Our model is consistent with a wide range of experiments, indicating that it captures some main characteristics of the signal transduction along the pathway. Investigation with the model reveals that the shuttling of the scaffold protein and the dephosphorylation of kinases involved in the MAPK cascade cooperate to regulate the response upon pheromone induction and to help preserve the fidelity of the mating signaling. We explored factors affecting the dose-response curves of this pathway and found that both negative feedback and concentrations of the proteins involved in the MAPK cascade play crucial roles. Contrary to some other MAPK systems where signaling sensitivity is being amplified successively along the cascade, here the mating signal is transmitted through the cascade in an almost linear fashion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.