ArticleBiophysical journal2006
K+ conduction in the selectivity filter of potassium channels is monitored by the charge distribution along their sequence.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Force field sensitivity of ion occupancy in potassium channels.Biophysical journal · 2026Article
- Functional characterization of two KCND3 variants associated with SCA 19/22 ataxia in Latin American families.Biological research · 2025Article
- A novel mutation KCNQ1p.Thr312del is responsible for long QT syndrome type 1.Heart and vessels · 2019Article
- Origin of the Shape of Current-Voltage Curve through Nanopores: A Molecular Dynamics Study.Scientific reports · 2016Article
- Self-Optimized Biological Channels in Facilitating the Transmembrane Movement of Charged Molecules.Journal of biophysics (Hindawi Publishing Corporation : Online) · 2016Article
- Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels.Journal of chemical theory and computation · 2013Article
- Pore waters regulate ion permeation in a calcium release-activated calcium channel.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Detailed Examination of a Single Conduction Event in a Potassium Channel.The journal of physical chemistry letters · 2013Article
- The mechanism of Na⁺/K⁺ selectivity in mammalian voltage-gated sodium channels based on molecular dynamics simulation.Biophysical journal · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Computer Simulations of Voltage-Gated Cation Channels.The journal of physical chemistry letters · 2012Article
- Ion conduction through the hERG potassium channel.PloS one · 2012Article
- Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation.Frontiers in pharmacology · 2012Article
- Counting ion and water molecules in a streaming file through the open-filter structure of the K channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Comparative study of the energetics of ion permeation in Kv1.2 and KcsA potassium channels.Biophysical journal · 2011Article
- Computational analysis of membrane proteins: the largest class of drug targets.Drug discovery today · 2009Review
- Importance of the peptide backbone description in modeling the selectivity filter in potassium channels.Biophysical journal · 2009Article
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2 authors.
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Abstract
Potassium channels display a high conservation of sequence of the selectivity filter (SF), yet nature has designed a variety of channels that present a wide range of absolute rates of K(+) permeation. In KcsA, the structural archetype for K channels, under physiological concentrations, two K(+) ions reside in the SF in configurations 1,3 (up state) and 2,4 (down state) and ion conduction is believed to follow a throughput cycle involving a transition between these states. Using free-energy calculations of KcsA, Kv1.2, and mutant channels, we show that this transition is characterized by a channel-dependent energy barrier. This barrier is strongly influenced by the charges partitioned along the sequence of each channel. These results unveil therefore how, for similar structures of the SF, the rate of K(+) turnover may be fine-tuned within the family of potassium channels.
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