Evidence map›Paper›PMID 16980314›Full record

SynthesisBMJ (Clinical research ed.)2006

Effects of calcium supplementation on bone density in healthy children: meta-analysis of randomised controlled trials.

Tania Winzenberg, Kelly Shaw, Jayne Fryer, Graeme Jones

Open access · bronzeAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 7 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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  9. Effects of milk powder intervention on bone mineral density and indicators related to bone metabolism in Chinese adolescents.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
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  11. The longitudinal effects of physical activity and dietary calcium on bone mass accrual across stages of pubertal development.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tania WinzenbergMenzies Research Institute, Private Bag 23, Hobart, Tas 7001, Australia. tania.winzenberg@utas.edu.au
Kelly Shaw
Jayne Fryer
Graeme Jones
Menzies School of Health Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and persists after supplementation stops.

designMeta-analysis. DATA SOURCES: Electronic bibliographic databases, hand searching of conference proceedings, and contacting authors for unpublished data. REVIEW

methodsWe included randomised placebo controlled trials of calcium supplementation in healthy children that lasted at least three months and had bone outcomes measured after at least six months of follow-up. Two reviewers independently extracted data and assessed quality. Meta-analyses predominantly used fixed effects models with outcomes given as standardised mean differences.

resultsWe included 19 studies involving 2859 children. Calcium supplementation had no effect on bone mineral density at the femoral neck or lumbar spine. There was a small effect on total body bone mineral content (standardised mean difference 0.14, 95% confidence interval 0.01 to 0.27) and upper limb bone mineral density (0.14, 0.04 to 0.24). This effect persisted after the end of supplementation only at the upper limb (0.14, 0.01 to 0.28). There was no evidence that sex, baseline calcium intake, pubertal stage, ethnicity, or level of physical activity modified the effect.

conclusionsThe small effect of calcium supplementation on bone mineral density in the upper limb is unlikely to reduce the risk of fracture, either in childhood or later life, to a degree of major public health importance.

Indexed as

AdolescentArm BonesBone DensityCalciumCalcium, DietaryChildChild, PreschoolDietary SupplementsFemur NeckFractures, BoneHumansLumbar VertebraeOsteoporosisRandomized Controlled Trials as TopicCalciumCalcium, Dietary

Identifiers

PMID16980314
PMCPMC1602024
OpenAlexW2151800838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.