ReviewBest practice & research. Clinical rheumatology2006
Treating very early rheumatoid arthritis.
Review in Best practice & research. Clinical rheumatology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00523692 (Remission Induction in Very Early Rheumatoid Arthritis), which is not on this map. Cited by 66 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Remission Induction in Very Early Rheumatoid Arthritis: a Comparison of Etanercept Plus Methotrexate Plus Steroid With Standard Therapy
Who cites it
66 citing papers in PubMed, 4 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Approaches and outcomes of adalimumab discontinuation in patients with well-controlled inflammatory arthritis: a systematic search and review.Pediatric rheumatology online journal · 2024Pooled it
- A Systematic Review to Identify the Effects of Biologics in the Feet of Patients with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2020Pooled it
- The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review.Rheumatology international · 2017Pooled it
- Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature.Arthritis care & research · 2013Pooled it
- Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound.Arthritis research & therapy · 2023Trial
- Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.Nature immunology · 2026Article
- Undifferentiated inflammatory arthritis in a tuberculosis-positive patient: a diagnostic and therapeutic challenge - a case report.Annals of medicine and surgery (2012) · 2025Article
- Prodromal symptoms of rheumatoid arthritis in a primary care database: variation by ethnicity and socioeconomic status.Rheumatology (Oxford, England) · 2025Article
- Diagnostic performance of optical spectral transmission compared to magnetic resonance imaging in patients with inflammatory arthritis.Arthritis research & therapy · 2025Article
- Bone Health in Patients with Rheumatoid Arthritis in Bahrain.Medicina (Kaunas, Lithuania) · 2024Article
- Can the General Public Be a Proxy for an "At-Risk" Group in a Patient Preference Study? A Disease Prevention Example in Rheumatoid Arthritis.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- Society of skeletal radiology position paper - recommendations for contrast use in musculoskeletal MRI: when is non-contrast imaging enough?Skeletal radiology · 2024Article
- Computational approaches in rheumatic diseases - Deciphering complex spatio-temporal cell interactions.Computational and structural biotechnology journal · 2023Review
- Article
- Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset.Rheumatology (Oxford, England) · 2022Article
- The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study.BMC rheumatology · 2022Article
- A Novel Ensemble-Based Technique for the Preemptive Diagnosis of Rheumatoid Arthritis Disease in the Eastern Province of Saudi Arabia Using Clinical Data.Computational and mathematical methods in medicine · 2022Article
- Radiographic changes in the temporomandibular joint related to medication in rheumatic diseases.Dento maxillo facial radiology · 2021Article
- Article
- Profiling of Serum Oxylipins During the Earliest Stages of Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is common and leads to joint damage due to persistent synovitis. The persistence of inflammation is maintained by hyperplastic stromal tissue, which drives the accumulation of leukocytes in the synovium. Aggressive treatment after the first 3-4 months of symptoms, with either disease modifying anti-rheumatic drugs or anti-tumor necrosis factor (TNF)-alpha therapy, reduces the rate of disease progression. However, it rarely switches off disease such that remission can be maintained without the continued need for immunosuppressive therapy. There is increasing evidence that the first few months after symptom onset represent a pathologically distinct phase of disease. This very early phase may translate into a therapeutic window of opportunity during which it may be possible to permanently switch off the disease process. The rationale for, and approaches to, treatment within this very early window are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.