ArticlePflugers Archiv : European journal of physiology1990
The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells.
Article in Pflugers Archiv : European journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Caffeine exacerbates seizure-induced death via postictal hypoxia.Scientific reports · 2023Article
- Pu-Erh Tea Relaxes the Thoracic Aorta of Rats by Reducing Intracellular Calcium.Frontiers in pharmacology · 2019Article
- Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction.The Journal of pharmacology and experimental therapeutics · 2016Article
- Caffeine in tea Camellia sinensis--content, absorption, benefits and risks of consumption.The journal of nutrition, health & aging · 2014Review
- Caffeine's Vascular Mechanisms of Action.International journal of vascular medicine · 2010Article
- The effects of caffeine on ATP-sensitive K(+) channels in smooth muscle cells from pig urethra.British journal of pharmacology · 2000Article
- Caffeine-sensitive calcium stores regulate synaptic transmission from retinal rod photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Possible mechanism of the potent vasoconstrictor actions of ryanodine on femoral arteries from spontaneously hypertensive rats.British journal of pharmacology · 1996Article
- Voltage-dependent suppression of calcium current by caffeine in single smooth muscle cells of the guinea-pig urinary bladder.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells.British journal of pharmacology · 1995Article
- Inhibition of muscarinic receptor-induced inositol phospholipid hydrolysis by caffeine, beta-adrenoceptors and protein kinase C in intestinal smooth muscle.British journal of pharmacology · 1995Article
- A caffeine- and ryanodine-sensitive intracellular Ca2+ store can act as a Ca2+ source and a Ca2+ sink in PC12 cells.The Biochemical journal · 1994Article
- Inhibitory effects of caffeine on secretagogue-induced catecholamine secretion from adrenal chromaffin cells of the guinea-pig.British journal of pharmacology · 1994Article
- Effects of caffeine on intracellular calcium, calcium current and calcium-dependent potassium current in anterior pituitary GH3 cells.Pflugers Archiv : European journal of physiology · 1994Article
- Ca2+ and Sr2+ entry induced Ca2+ release from the intracellular Ca2+ store in smooth muscle cells of rat portal vein.The Journal of physiology · 1993Article
- Evidence for multiple open states of the Ca2+ channels in smooth muscle cells isolated from the guinea-pig detrusor.The Journal of physiology · 1993Article
- Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes.The Journal of physiology · 1993Article
- Effects of excitatory neurotransmitters on Ca2+ channel current in smooth muscle cells isolated from guinea-pig urinary bladder.British journal of pharmacology · 1993Article
- Caffeine-induced decreases in the inward rectifier potassium and the inward calcium currents in rat ventricular myocytes.British journal of pharmacology · 1993Article
- The action of amlodipine on voltage-operated calcium channels in vascular smooth muscle.British journal of pharmacology · 1993Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The effect of caffeine on inward current carried by barium ions through voltage-dependent calcium channels has been investigated in single rabbit ear artery cells using whole-cell voltage-clamp techniques. Caffeine (1-30 mM) caused a rapid and reversible concentration-dependent blockade of barium current and a related compound, 3-isobutyl-1-methylxanthine (IBMX), was a more potent inhibitor of barium current. Caffeine-induced inhibition of barium current showed no voltage- or use-dependence and caffeine did not alter the steady-state inactivation of barium current. The effect of caffeine was not blocked by extracellular or by intracellular ryanodine or inclusion of both 5 mM 1,2-bis(2-aminophenoxy)-ethane N,N,N',N',-tetraacetic acid (BAPTA) and 2 mM ethylene glycol-bis(beta-amino ethyl ether) N,N,N',N',-tetraacetic acid (EGTA) in the intracellular solution. Rolipram and M&B 22984, non-xanthine inhibitors of phosphodiesterase, did not diminish inward barium current. The data indicate that caffeine and IBMX block voltage-operated calcium channels and it is suggested that this is due to a direct interaction of methylxanthines with the calcium channel.
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