Evidence map›Paper›PMID 16979302›Full record

ArticlePathology, research and practice2006

Postmortem findings and opportunistic infections in HIV-positive patients from a public hospital in Peru.

Dominique Eza, Gustavo Cerrillo, David A J Moore, Cecilia Castro, Eduardo Ticona, Domingo Morales, Jose Cabanillas, Fernando Barrantes, Alejandro Alfaro, Alejandro Benavides and 5 more

Abstract read
In one paragraph

Article in Pathology, research and practice, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Journal of fungi (Basel, Switzerland) · 2022
    Article
  4. Quantifying Deaths from Aspergillosis in HIV Positive People.Journal of fungi (Basel, Switzerland) · 2022
    Review
  5. Article
  6. Article
  7. Approach to an Intracranial Mass in Patients With HIV.Current neurology and neuroscience reports · 2020
    Review
  8. Article
  9. Article
  10. Serious fungal infections in Peru.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dominique EzaDepartamento de Laboratorio y Anatomía Patológica, Hospital Nacional Dos de Mayo, Parque Historia de la Medicina Peruana s/n, Altura de Cuadra 13 Avenida Grau, Lima 1, Perú. dominiqueeeza@yahoo.co.uk
Gustavo Cerrillo
David A J Moore
Cecilia Castro
Eduardo Ticona
Domingo Morales
Jose Cabanillas
Fernando Barrantes
Alejandro Alfaro
Alejandro Benavides
Arturo Rafael
Gilberto Valladares
Fernando Arevalo
Carlton A Evans
Robert H Gilman

Funding

Wellcome Trust 057434
6 · The paper itself

Abstract

There is a paucity of HIV autopsy data from South America and none that document the postmortem findings in patients with HIV/AIDS in Peru. The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital postmortems, performed between 1999 and 2004, were included in this retrospective analysis. The primary cause of death was established in 12 patients: one died of neoplasia and 11 of infectious diseases, including 3 from pulmonary infection, 7 from disseminated infection, and 2 from central nervous system infection (one case had dual pathology). Opportunistic infections were identified in 14 cases, comprising cytomegalovirus, histoplasmosis, cryptococcosis, toxoplasmosis, Pneumocystis pneumonia, aspergillosis, tuberculosis, varicella zoster virus, and cryptosporidiosis. Fourteen patients had at least one AIDS-related disease that had been neither clinically suspected nor diagnosed premortem. Moreover, 82% of the diagnoses considered to be of important clinical significance had not been suspected antemortem. The spectrum and frequency of certain opportunistic infections differed from other South American autopsy studies, highlighting the importance of performing HIV/AIDS postmortems in resource-limited countries where locally specific disease patterns may be observed.

Indexed as

Cause of DeathAdultAgedAIDS-Related Opportunistic InfectionsAutopsyFemaleHIV InfectionsHospitals, PublicHumansMaleMiddle AgedPeruRetrospective Studies

Identifiers

PMID16979302
PMCPMC2912516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.