ArticleAtherosclerosis2007
Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging.
Article in Atherosclerosis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Assessment of Therapeutic Response to Statin Therapy in Patients With Intracranial or Extracranial Carotid Atherosclerosis by Vessel Wall MRI: A Systematic Review and Updated Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Carotid atherosclerotic lesion analysis in 3D based on distance encoding in mesh representation.International journal of computer assisted radiology and surgery · 2025Article
- Relationship between fetal-type posterior cerebral artery and basilar artery atherosclerosis.Frontiers in neurology · 2025Article
- Pathophysiology of carotid atherosclerosis: Calcification, intraplaque haemorrhage and pulse pressure as key players.European journal of radiology · 2024Article
- Learning carotid vessel wall segmentation in black-blood MRI using sparsely sampled cross-sections from 3D data.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- The Role of High-Resolution Magnetic Resonance Imaging in Cerebrovascular Disease: A Narrative Review.Brain sciences · 2023Review
- Quantification of carotid plaque composition with a multi-contrast atherosclerosis characterization (MATCH) MRI sequence.Frontiers in cardiovascular medicine · 2023Article
- Predicting Coronary Stenosis Progression Using Plaque Fatigue From IVUS-Based Thin-Slice Models: A Machine Learning Random Forest Approach.Frontiers in physiology · 2022Article
- A Review on Joint Carotid Intima-Media Thickness and Plaque Area Measurement in Ultrasound for Cardiovascular/Stroke Risk Monitoring: Artificial Intelligence Framework.Journal of digital imaging · 2021Review
- Extracranial Vascular Disease: Carotid Stenosis and Plaque Imaging.Neuroimaging clinics of North America · 2021Review
- Magnetic resonance imaging of carotid plaques: current status and clinical perspectives.Annals of translational medicine · 2020Review
- Carotid Vessel Wall Imaging on CTA.AJNR. American journal of neuroradiology · 2020Review
- Association between age and progression of carotid artery atherosclerosis: a serial high resolution magnetic resonance imaging study.The international journal of cardiovascular imaging · 2019Article
- Intensive Lipid-Lowering Therapy Ameliorates Asymptomatic Intracranial Atherosclerosis.Aging and disease · 2019 · on this mapArticle
- Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2018Article
- Coronary Artery Plaque Imaging.Current atherosclerosis reports · 2017Review
- Bilateral symmetry of human carotid artery atherosclerosis: a multi-contrast weighted MR study.The international journal of cardiovascular imaging · 2016Article
- Prognostic value of cardiovascular MR imaging biomarkers on outcome in peripheral arterial disease: a 6-year follow-up pilot study.The international journal of cardiovascular imaging · 2016Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The purpose of this in vivo MRI study was to quantify changes in atherosclerotic plaque morphology prospectively and to identify factors that may alter the rate of progression in plaque burden. Sixty-eight asymptomatic subjects with >or=50% stenosis, underwent serial carotid MRI examinations over an 18-month period. Clinical risk factors for atherosclerosis, and medications were documented prospectively. The wall and total vessel areas, matched across time-points, were measured from cross-sectional images. The normalized wall index (NWI=wall area/total vessel area), as a marker of disease severity, was documented at baseline and at 18 months. Multiple regression analysis was used to correlate risk factors and morphological features of the plaque with the rate of progression/regression. On average, the wall area increased by 2.2% per year (P=0.001). Multiple regression analysis demonstrated that statin therapy (P=0.01) and a normalized wall index >0.64 (P=0.001) were associated with a significantly reduced rate of progression in mean wall area. All other documented risk factors were not significantly associated with changes in wall area. Findings from this study suggest that increased normalized wall index and the use of statin therapy are associated with reduced rates of plaque progression amongst individuals with advanced, asymptomatic carotid atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.