ArticleIntensive care medicine2006
Hyperbaric oxygen therapy prevents coagulation disorders in an experimental model of multiple organ failure syndrome.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Higher admission IL-6 levels are associated with higher platelet levels at discharge in sepsis patients.Annals of medicine and surgery (2012) · 2026Article
- Hyperbaric oxygen therapy in the treatment of severe gastric laceration with active bleeding: A case report.World journal of gastrointestinal endoscopy · 2025Article
- Effects of Hyperbaric Oxygen Therapy on Hemogram, Serum Biochemistry and Coagulation Parameters of Dogs Undergoing Elective Laparoscopic-Assisted Ovariohysterectomy.Animals : an open access journal from MDPI · 2024Article
- From dermatological conditions to COVID-19: Reasoning for anticoagulation, suppression of inflammation, and hyperbaric oxygen therapy.Dermatologic therapy · 2021Review
- Lessons from dermatology about inflammatory responses in Covid-19.Reviews in medical virology · 2020Review
- Increased Efficacy of Antivenom Combined with Hyperbaric Oxygen onChinese medical journal · 2018Article
- Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice.Frontiers in physiology · 2018Article
- Observational
- Dimethyl sulfoxide inhibits zymosan-induced intestinal inflammation and barrier dysfunction.World journal of gastroenterology · 2015Article
- Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology.Intensive care medicine · 2007Review
- Recently published papers: the Jekyll and Hyde of oxygen, neuromuscular blockade and good vibrations?Critical care (London, England) · 2007Review
- Can (hyperbaric) oxygen turn off the motor of multiorgan dysfunction?Intensive care medicine · 2006Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effects of hyperbaric oxygen (HBO) therapy on the coagulation cascade using an experimental model of multiple organ failure syndrome (MOFS).
designMOFS was induced by zymosan (500mg/kg i.p.) in rats. HBO therapy (2ATA) was administered in a cylindrical steel chamber 4 and 11h after zymosan administration. In a separate set of experiments animals were monitored for 72h, and systemic toxicity was scored.
interventionEighteen hours after zymosan administration, rats were killed and blood samples were used for analysis of hemocoagulative parameters, hemodynamics, and arterial blood gas. MAIN
resultsZymosan administration caused MOFS by affecting the coagulation cascade, as shown by a significant increase in plasma levels of fibrinogen, tissue plasminogen activator, inhibitor of tissue plasminogen activator of type 1, and plasma levels of fibrin degradation products vs. control rats. Zymosan-induced MOFS was also characterized by a significant increase in von Willebrand antigen plasma levels vs. controls. Moreover, zymosan administration induced a significant fall in mean arterial blood pressure and alteration in blood gas values. HBO therapy significantly reduced the derangements of coagulation cascade, the fall in mean blood pressure and alteration in blood gas induced by zymosan administration.
conclusionsThe hypercoagulability induced by zymosan could be responsible for organ failure and death. Our data demonstrate that HBO therapy significantly prevents the alteration in the coagulation cascade and arterial blood gas in an experimental model of MOFS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.