Evidence map›Paper›PMID 16973955›Full record

ReviewBlood2007

Hematologic manifestations of celiac disease.

Thorvardur R Halfdanarson, Mark R Litzow, Joseph A Murray

Open access · greenAbstract readReview
In one paragraph

Review in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 6 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 6 syntheses or guidelines pooled it, 374 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. ACG clinical guidelines: diagnosis and management of celiac disease.The American journal of gastroenterology · 2013
    Guideline
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thorvardur R HalfdanarsonDivision of Hematology, Mayo Clinic College of Medicine, 200 First St, SW, Rochester MN 55905, USA. halfdanarson.thorvardur@mayo.edu
Mark R Litzow
Joseph A Murray
Mayo Clinic in Arizona · US

Funding

EPIDEMIOLOGY OF CELIAC DISEASE--A POPULATION BASED STUDYR01DK057892 · NIDDK · MAYO CLINIC ROCHESTER · PI MURRAY, JOSEPH A · 2000 to 2010
$3.9M
A HLA Mouse Model for Gluten Sensitivity and EnteropathyR01DK071003 · NIDDK · MAYO CLINIC ROCHESTER · PI MURRAY, JOSEPH A · 2006 to 2009
$1.1M
A HLA Mouse Model for Gluten Sensitivity and EnteropathyR56DK071003 · NIDDK · MAYO CLINIC ROCHESTER · PI MURRAY, JOSEPH A · 2010 to 2010
$394k
NIDDK NIH HHS DK 57892NIDDK NIH HHS DK 71003NIDDK NIH HHS R01 DK057892NIDDK NIH HHS R01 DK071003NIDDK NIH HHS R56 DK071003
6 · The paper itself

Abstract

Celiac disease is a common systemic disorder that can have multiple hematologic manifestations. Patients with celiac disease may present to hematologists for evaluation of various hematologic problems prior to receiving a diagnosis of celiac disease. Anemia secondary to malabsorption of iron, folic acid, and/or vitamin B12 is a common complication of celiac disease and many patients have anemia at the time of diagnosis. Celiac disease may also be associated with thrombocytosis, thrombocytopenia, leukopenia, venous thromboembolism, hyposplenism, and IgA deficiency. Patients with celiac disease are at increased risk of being diagnosed with lymphoma, especially of the T-cell type. The risk is highest for enteropathy-type T-cell lymphoma (ETL) and B-cell lymphoma of the gut, but extraintestinal lymphomas can also be seen. ETL is an aggressive disease with poor prognosis, but strict adherence to a gluten-free diet may prevent its occurrence.

Indexed as

AnemiaCeliac DiseaseHematologic DiseasesHumansSplenic Diseases

Identifiers

PMID16973955
PMCPMC1785098
OpenAlexW2001460243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.