ArticleProceedings of the National Academy of Sciences of the United States of America2006
Diversity of zebrafish peripheral oscillators revealed by luciferase reporting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 68 citations in OpenAlex.
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- Clock genes expression and locomotor activity are altered along the light-dark cycle in transgenic zebrafish overexpressing growth hormone.Transgenic research · 2017Article
- Rhythms in the endocrine system of fish: a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
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- The Retina and Other Light-sensitive Ocular Clocks.Journal of biological rhythms · 2016Review
- An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function.Genome research · 2015Article
- The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.Computational and mathematical methods in medicine · 2015Article
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- Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish.PLoS computational biology · 2013Article
- The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing.Frontiers in molecular neuroscience · 2012Article
- Light and melatonin schedule neuronal differentiation in the habenular nuclei.Developmental biology · 2011Article
- A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception.PLoS biology · 2011Article
- Circadian rhythms in the pineal organ persist in zebrafish larvae that lack ventral brain.BMC neuroscience · 2011Article
- Diurnal Variation in Peripheral (Hair) vs Central (Saliva) HPA Axis Cortisol Concentrations.Clinical medicine insights. Endocrinology and diabetes · 2010Article
- Circadian clock genes of goldfish, Carassius auratus: cDNA cloning and rhythmic expression of period and cryptochrome transcripts in retina, liver, and gut.Journal of biological rhythms · 2009Article
- Novel functions for Period 3 and Exo-rhodopsin in rhythmic transcription and melatonin biosynthesis within the zebrafish pineal organ.Brain research · 2008Article
- The Drosophila circadian pacemaker circuit: Pas De Deux or Tarantella?Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In various multicellular organisms, circadian clocks are present not only in the central nervous system, but also in peripheral organs and tissues. In mammals peripheral oscillators are not directly responsive to light, but are entrained by the central oscillator in the suprachiasmatic nucleus. These individual oscillators are diverse in their free-running periods and phases. In contrast, cultured peripheral tissues and cell lines from zebrafish are not only rhythmic, but can also be directly entrained by light. Because of the convenience of studying rhythms in cultured cells, however, little has been known about properties of individual oscillators in intact zebrafish. Here, we show the remarkable diversity and consistency of oscillator properties in various peripheral organs and tissues from the period3-luciferase (per3-luc) transgenic zebrafish. Tissue-dependent differences were found in free-running period, phase, response to light, and temperature compensation. Furthermore, cycling amplitudes were reduced at lower temperatures in some, but not all, of the organs tested. Finally, we found that per3-luc rhythms can free run in both constant dark and constant light with remarkably similar amplitudes, phases, and periods, despite the fact that the mRNA of per2 and per1 has been shown not to oscillate in constant light.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.