ArticleProceedings of the National Academy of Sciences of the United States of America2006
The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- The T-type calcium channelosome.Pflugers Archiv : European journal of physiology · 2024Review
- The life cycle of voltage-gated CaNeuronal signaling · 2021Review
- Ion Channel Function and Electrical Excitability in the Zona Glomerulosa: A Network Perspective on Aldosterone Regulation.Annual review of physiology · 2021Review
- Article
- Neuronal Cav3 channelopathies: recent progress and perspectives.Pflugers Archiv : European journal of physiology · 2020Review
- Genetic T-type calcium channelopathies.Journal of medical genetics · 2020Review
- The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.The Journal of biological chemistry · 2019Review
- GPCR regulation of secretion.Pharmacology & therapeutics · 2018Review
- Inhibitory peptidergic modulation ofeLife · 2017Article
- CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy.Genes & development · 2015Article
- Redox regulation of neuronal voltage-gated calcium channels.Antioxidants & redox signaling · 2014Review
- Article
- Voltage-gated calcium channels.Cold Spring Harbor perspectives in biology · 2011Review
- T-type voltage-gated calcium channels as targets for the development of novel pain therapies.British journal of pharmacology · 2011Review
- Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation.Journal of medicine and life · 2011Review
- Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.The Journal of biological chemistry · 2011Article
- In vivo expression of G-protein beta1gamma2 dimer in adult mouse skeletal muscle alters L-type calcium current and excitation-contraction coupling.The Journal of physiology · 2010Article
- Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway.Free radical biology & medicine · 2010Article
- Protein kinase A activity controls the regulation of T-type CaV3.2 channels by Gbetagamma dimers.The Journal of biological chemistry · 2009Article
- G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3.Biochemical and biophysical research communications · 2008Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Gbetagamma, a ubiquitous second messenger, relays external signals from G protein-coupled receptors to networks of intracellular effectors, including voltage-dependent calcium channels. Unlike high-voltage-activated Ca(2+) channels, the inhibition of low-voltage-activated Ca(2+) channels is subtype-dependent and mediated selectively by Gbeta(2)-containing dimers. Yet, the molecular basis for this exquisite selectivity remains unknown. Here, we used pure recombinant Gbetagamma subunits to establish that the Gbeta(2)gamma(2) dimer can selectively reconstitute the inhibition of alpha(1H) channels in isolated membrane patches. This inhibition is the result of a reduction in channel open probability that is not accompanied by a change in channel expression or an alteration in active-channel gating. By exchanging residues between the active Gbeta(2) subunit and the inactive Gbeta(1) subunit, we identified a cluster of amino acids that functionally distinguish Gbeta(2) from other Gbeta subunits. These amino acids on the beta-torus identify a region that is distinct from those regions that contact the Galpha subunit or other effectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.