ArticleProceedings of the National Academy of Sciences of the United States of America2006
Self-assembly of receptor/signaling complexes in bacterial chemotaxis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy.Nature communications · 2025Article
- Engineered chemotaxis core signaling units indicate a constrained kinase-off state.Science signaling · 2020Article
- His-Tag-Mediated Dimerization of Chemoreceptors Leads to Assembly of Functional Nanoarrays.Biochemistry · 2017Article
- Preformed Soluble Chemoreceptor Trimers That Mimic Cellular Assembly States and Activate CheA Autophosphorylation.Biochemistry · 2015Article
- CheA-receptor interaction sites in bacterial chemotaxis.Journal of molecular biology · 2012Article
- Noise characteristics of the Escherichia coli rotary motor.BMC systems biology · 2011Article
- Core unit of chemotaxis signaling complexes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Electron cryotomography.Cold Spring Harbor perspectives in biology · 2010Review
- Article
- Kinase-active signaling complexes of bacterial chemoreceptors do not contain proposed receptor-receptor contacts observed in crystal structures.Biochemistry · 2010Article
- Universal architecture of bacterial chemoreceptor arrays.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Complete genome sequence of the chemolithoautotrophic marine magnetotactic coccus strain MC-1.Applied and environmental microbiology · 2009Article
- Mutational analysis of the connector segment in the HAMP domain of Tsr, the Escherichia coli serine chemoreceptor.Journal of bacteriology · 2008Article
- Receptor density balances signal stimulation and attenuation in membrane-assembled complexes of bacterial chemotaxis signaling proteins.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Location and architecture of the Caulobacter crescentus chemoreceptor array.Molecular microbiology · 2008Article
- Bacterial chemoreceptors: high-performance signaling in networked arrays.Trends in biochemical sciences · 2008Review
- Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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6 authors.
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Abstract
Escherichia coli chemotaxis is mediated by membrane receptor/histidine kinase signaling complexes. Fusing the cytoplasmic domain of the aspartate receptor, Tar, to a leucine zipper dimerization domain produces a hybrid, lzTar(C), that forms soluble complexes with CheA and CheW. The three-dimensional reconstruction of these complexes was different from that anticipated based solely on structures of the isolated components. We found that analogous complexes self-assembled with a monomeric cytoplasmic domain fragment of the serine receptor without the leucine zipper dimerization domain. These complexes have essentially the same size, composition, and architecture as those formed from lzTar(C). Thus, the organization of these receptor/signaling complexes is determined by conserved interactions between the constituent chemotaxis proteins and may represent the active form in vivo. To understand this structure in its cellular context, we propose a model involving parallel membrane segments in receptor-mediated CheA activation in vivo.
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