ArticleThe British journal of ophthalmology2007
Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population.
Article in The British journal of ophthalmology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Association of glutathione S transferases polymorphisms with glaucoma: a meta-analysis.PloS one · 2013Pooled it
- Article
- Association of Genetic Polymorphisms in Oxidative Stress and Inflammation Pathways with Glaucoma Risk and Phenotype.Journal of clinical medicine · 2021Article
- Glutathione S-Transferase Omega-2 and Transforming Growth Factor-Journal of ophthalmology · 2021Article
- Do GSTM1 and GSTT1 polymorphisms influence the risk of developing mitochondrial diseases in a Tunisian population?Environmental science and pollution research international · 2018Article
- Article
- Frontiers of Complex Disease Mechanisms: Membrane Surface Tension May Link Genotype to Phenotype in Glaucoma.Frontiers in cell and developmental biology · 2018Article
- Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes.Scientific reports · 2017Article
- An Updated Review on the Genetics of Primary Open Angle Glaucoma.International journal of molecular sciences · 2015Review
- An Updated Meta-Analysis: Risk Conferred by Glutathione S-Transferases (GSTM1 and GSTT1) Polymorphisms to Age-Related Cataract.Journal of ophthalmology · 2015Review
- Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma.Iranian journal of basic medical sciences · 2014Article
- The Role of Oxidative Stress and Vascular Insufficiency in Primary Open Angle Glaucoma.Clujul medical (1957) · 2014Review
- Differential cell death and Bcl-2 expression in the mouse retina after glutathione decrease by systemic D,L-buthionine sulphoximine administration.Molecules and cells · 2013Article
- Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations.Human genomics · 2012Review
- Circulating total glutathione in normal tension glaucoma patients: comparison with normal control subjects.Korean journal of ophthalmology : KJO · 2012Article
- Age-related macular degeneration and genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1).Molecular biology reports · 2012Article
- Glutathione S-transferases polymorphisms confer susceptibility to senile cortical cataract in the Han Chinese population.Molecular vision · 2012Article
- Complex genetic mechanisms in glaucoma: an overview.Indian journal of ophthalmology · 2011Review
- Genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) and susceptibility to pre-eclampsia: a case-control study and a meta-analysis.EXCLI journal · 2011Article
- Is the GSTM1 null polymorphism a risk factor in primary open angle glaucoma?Molecular vision · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).
aimTo determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.
methodsUsing a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.
resultsThe GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).
conclusionThe GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.