ArticleJournal of clinical microbiology2006
Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 83 citations in OpenAlex.
- Influence of antituberculosis drug resistance and Mycobacterium tuberculosis lineage on outcome in HIV-associated tuberculous meningitis.Antimicrobial agents and chemotherapy · 2012Trial
- Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026Review
- Development of innovative multi-epitope mRNA vaccine against central nervous system tuberculosis using in silico approaches.PloS one · 2024Article
- Central Nervous System Tuberculosis in a Murine Model: Neurotropic Strains or a New Pathway of Infection?Pathogens (Basel, Switzerland) · 2023Article
- Bacterial meningitis in Africa.Frontiers in neurology · 2023Review
- Impact of pathobiological diversity of Mycobacterium tuberculosis on clinical features and lethal outcome of tuberculosis.BMC microbiology · 2022Article
- A comparative analysis of molecular genotypes ofFrontiers in cellular and infection microbiology · 2022Article
- Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.Scientific reports · 2021Article
- Immunization withJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- The pathogenesis of tuberculous meningitis.Journal of leukocyte biology · 2019Review
- Role of MIRU-VNTR and spoligotyping in assessing the genetic diversity of Mycobacterium tuberculosis in Henan Province, China.BMC infectious diseases · 2018Article
- Bacterial risk factors for treatment failure and relapse among patients with isoniazid resistant tuberculosis.BMC infectious diseases · 2018Article
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- Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea.BMC microbiology · 2014Article
- Consequences of genomic diversity in Mycobacterium tuberculosis.Seminars in immunology · 2014Review
- Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.PLoS pathogens · 2014Article
- Therapy duration and long-term outcomes in extra-pulmonary tuberculosis.BMC infectious diseases · 2014Article
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- Single nucleotide polymorphisms in Mycobacterium tuberculosis and the need for a curated database.Tuberculosis (Edinburgh, Scotland) · 2013Review
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strains among Mycobacterium tuberculosis isolates from the cerebrospinal fluid of HIV-positive (n = 35) and HIV-negative (n = 187) patients in Ho Chi Minh City was determined. The Beijing genotype was significantly associated with HIV status (odds ratio [OR] = 2.95 [95% confidence interval {CI}, 1.38 to 6.44]; P = 0.016), resistance to any drug (OR = 3.34 [95% CI, 1.87 to 5.95]; P < 0.001) and multidrug resistance (Fisher's exact test; P = 0.001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.