ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
DARPP-32 involvement in the photic pathway of the circadian system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- Epigenetic control and the circadian clock: linking metabolism to neuronal responses.Neuroscience · 2014Review
- cGMP-phosphodiesterase inhibition enhances photic responses and synchronization of the biological circadian clock in rodents.PloS one · 2012Article
- Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms.Clinical psychology review · 2011Review
- Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.PloS one · 2011Article
- Joining the dots: from chromatin remodeling to neuronal plasticity.Current opinion in neurobiology · 2010Review
- Dopamine and aging: intersecting facets.Neurochemical research · 2009Review
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- The circadian clock system in the mammalian retina.BioEssays : news and reviews in molecular, cellular and developmental biology · 2008Review
- Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms.Psychopharmacology · 2007Article
- Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cellular localization and function of DARPP-32 in the rodent retina.The European journal of neuroscience · 2007Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The multifunctional regulator of protein kinases and phosphatases dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is an important molecular target of the dopamine signaling pathway. In the present study, we investigated the possible involvement of DARPP-32 regulation in the circadian system using DARPP-32 knock-out (KO) mice. These mice showed normal entrainment to a 12 h light/dark cycle and free run in constant darkness with a period similar to that of wild-type controls. After light exposure, however, the behavioral phase-delay response and the expression of light-induced clock gene mPer2 were attenuated in the DARPP-32 KO mice. Attenuated phase delays were also seen in animals bearing a point mutation in DARPP-32 at the PKA (Thr34) but not at the casein kinase I (Ser130) phosphorylation site. We next examined DARPP-32 expression in the retina and intergeniculate leaflet (IGL), both of which convey light information to the suprachiasmatic nucleus (SCN), the locus of a master circadian clock, and in the SCN itself. DARPP-32 was expressed in the retina but not in the IGL or the SCN. The results indicate that DARPP-32 is involved in the retinal pathway transmitting photic information that resets the circadian clock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.