ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Receptor and transmitter release properties set the time course of retinal inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 79 citations in OpenAlex.
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Afferent input differentially regulates establishment and maintenance of synapses in the mammalian retina.Scientific reports · 2025Article
- Retinal bipolar cells borrow excitability from electrically coupled inhibitory interneurons to amplify excitatory synaptic transmission.bioRxiv : the preprint server for biology · 2024Article
- Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina.iScience · 2024Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- The effects of early diabetes on inner retinal neurons.Visual neuroscience · 2020Article
- Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2020Article
- Light-evoked glutamate transporter EAAT5 activation coordinates with conventional feedback inhibition to control rod bipolar cell output.Journal of neurophysiology · 2020Article
- LRRTM4: A Novel Regulator of Presynaptic Inhibition and Ribbon Synapse Arrangements of Retinal Bipolar Cells.Neuron · 2020Article
- Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.Cell death & disease · 2019Article
- Reductions in Calcium Signaling Limit Inhibition to Diabetic Retinal Rod Bipolar Cells.Investigative ophthalmology & visual science · 2019Article
- Article
- Synaptic inhibition tunes contrast computation in the retina.Visual neuroscience · 2019Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF α ganglion cells in the rabbit retina.The Journal of physiology · 2018Article
- Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Light adaptation alters inner retinal inhibition to shape OFF retinal pathway signaling.Journal of neurophysiology · 2016Article
- Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.Investigative ophthalmology & visual science · 2016Article
- In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing.Experimental eye research · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic inhibition is determined by the properties of postsynaptic receptors, neurotransmitter release, and clearance, but little is known about how these factors shape sensation-evoked inhibition. The retina is an ideal system to investigate inhibition because it can be activated physiologically with light, and separate inhibitory pathways can be assayed by recording from rod bipolar cells that possess distinct glycine, GABA(A), and GABA(C) receptors (R). We show that receptor properties differentially shape spontaneous IPSCs, whereas both transmitter release and receptor properties shape light-evoked (L) IPSCs. GABA(C)R-mediated IPSCs decayed the slowest, whereas glycineR- and GABA(A)R-mediated IPSCs decayed more rapidly. Slow GABA(C)Rs determined the L-IPSC decay, whereas GABA(A)Rs and glycineRs, which mediated rapid onset responses, determined the start of the L-IPSC. Both fast and slow inhibitory inputs distinctly shaped the output of rod bipolar cells. The slow GABA(C)Rs truncated glutamate release, making the A17 amacrine cell L-EPSCs more transient, whereas the fast GABA(A)R and glycineRs reduced the initial phase of glutamate release, limiting the peak amplitude of the L-EPSC. Estimates of transmitter release time courses suggested that glycine release was more prolonged than GABA release. The time course of GABA release activating GABA(C)Rs was slower than that activating GABA(A)Rs, consistent with spillover activation of GABA(C)Rs. Thus, both postsynaptic receptor and transmitter release properties shape light-evoked inhibition in retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.