ArticleJournal of medical genetics2007
Ultra-high resolution array painting facilitates breakpoint sequencing.
Article in Journal of medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosome-specific DNA sequencing.BMC genomics · 2016Article
- Nonallelic homologous recombination between retrotransposable elements is a driver of de novo unbalanced translocations.Genome research · 2013Article
- Characterising chromosome rearrangements: recent technical advances in molecular cytogenetics.Heredity · 2012Review
- Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes.Journal of cellular and molecular medicine · 2010Article
- Breakpoint analysis of balanced chromosome rearrangements by next-generation paired-end sequencing.European journal of human genetics : EJHG · 2010Article
- AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Molecular cell · 2009Article
- Array painting: a protocol for the rapid analysis of aberrant chromosomes using DNA microarrays.Nature protocols · 2009Article
- Estimating genome-wide copy number using allele-specific mixture models.Journal of computational biology : a journal of computational molecular cell biology · 2008Article
- Mapping translocation breakpoints by next-generation sequencing.Genome research · 2008Article
- Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes.Oncogene · 2008Article
- A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis.Cytogenetic and genome research · 2008Article
- Methods and strategies for analyzing copy number variation using DNA microarrays.Nature genetics · 2007Review
- Mapping translocation breakpoints using a wheat microarray.Nucleic acids research · 2007Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo describe a considerably advanced method of array painting, which allows the rapid, ultra-high resolution mapping of translocation breakpoints such that rearrangement junction fragments can be amplified directly and sequenced.
methodUltra-high resolution array painting involves the hybridisation of probes generated by the amplification of small numbers of flow-sorted derivative chromosomes to oligonucleotide arrays designed to tile breakpoint regions at extremely high resolution. RESULTS AND DISCUSSION: How ultra-high resolution array painting of four balanced translocation cases rapidly and efficiently maps breakpoints to a point where junction fragments can be amplified easily and sequenced is demonstrated. With this new development, breakpoints can be mapped using just two array experiments: the first using whole-genome array painting to tiling resolution large insert clone arrays, the second using ultra-high-resolution oligonucleotide arrays targeted to the breakpoint regions. In this way, breakpoints can be mapped and then sequenced in a few weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.