ArticleJournal of virology2006
Selection of early-occurring mutations dictates hormone-independent progression in mouse mammary tumor lines.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer.The Journal of pathology · 2022Article
- Incidence of HPVs, EBV, and MMTV-Like Virus in Breast Cancer in Qatar.Intervirology · 2022Article
- The role of R-spondin proteins in cancer biology.Oncogene · 2021Review
- Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein-Barr Virus (EBV).Frontiers in oncology · 2018Review
- Article
- Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.Oncogene · 2015Article
- Article
- The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.Journal of cellular biochemistry · 2012Review
- Novel common integration sites targeted by mouse mammary tumor virus insertion in mammary tumors have oncogenic activity.PloS one · 2011Article
- Review
- Common integration sites for MMTV in viral induced mouse mammary tumors.Journal of mammary gland biology and neoplasia · 2008Review
- MMTV-induced pregnancy-dependent mammary tumors : early history and new perspectives.Journal of mammary gland biology and neoplasia · 2008Review
- Models, mechanisms and clinical evidence for cancer dormancy.Nature reviews. Cancer · 2007Review
- Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling.Breast cancer research : BCR · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Mice harboring three mouse mammary tumor virus (MMTV) variants develop pregnancy-dependent (PD) tumors that progress to pregnancy-independent (PI) behavior through successive passages. Herein, we identified 10 predominant insertions in PI transplants from 8 independent tumor lines. These mutations were also detected in small cell populations in the early PD passages. In addition, we identified a new viral insertion upstream of the gene Rspo3, which is overexpressed in three of the eight independent tumor lines and codes for a protein very similar to the recently described protein encoded by Int7. This study suggests that during progression towards hormone independence, clonal expansion of cells with specific mutations might be more relevant than the occurrence of new MMTV insertions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.