ArticleJournal of virology2006
Molecular epidemiology of the foot-and-mouth disease virus outbreak in the United Kingdom in 2001.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 167 citations in OpenAlex.
- Article
- Evaluation of amplicon-based nanopore sequencing for foot-and-mouth disease viruses in clinical and environmental samples.Microbiology spectrum · 2026Article
- Single dose of foot-and-mouth disease peptide vaccine fully protects swine and achieves intraserotype crossed neutralization.NPJ vaccines · 2025Article
- Universal amplification and sequencing of foot-and-mouth disease virus complete genomes using nanopore technology.BMC genomics · 2025Article
- Distinct mutations emerge in the genome of serotype O foot-and-mouth disease virus during persistence in cattle.Journal of virology · 2025Article
- Phylodynamic analysis of foot-and-mouth disease virus evolution in Mar Chiquita, Argentina.Archives of virology · 2024Article
- Pathological and genetic characterization of foot and mouth disease viruses collected from cattle and water buffalo in Egypt.PloS one · 2023Article
- Evaluating the potential of whole-genome sequencing for tracing transmission routes in experimental infections and natural outbreaks of bovine respiratory syncytial virus.Veterinary research · 2022Article
- Establishing an In Vitro System to Assess How Specific Antibodies Drive the Evolution of Foot-and-Mouth Disease Virus.Viruses · 2022Article
- Molecular detection, phylogenetic analysis and genetic diversity of recently isolated foot-and-mouth disease virus serotype A African topotype, Genotype IV.Virology journal · 2022Article
- Polymerase Fidelity Contributes to Foot-and-Mouth Disease Virus Pathogenicity and TransmissibilityJournal of virology · 2020Article
- Article
- Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection.Molecules (Basel, Switzerland) · 2020Article
- Viral genomics in Ebola virus research.Nature reviews. Microbiology · 2020Review
- Towards improvements in foot-and-mouth disease vaccine performance.Acta veterinaria Scandinavica · 2020Review
- Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the foot-and-mouth disease virus capsid.PLoS pathogens · 2020Article
- Genomic analysis of respiratory syncytial virus infections in households and utility in inferring who infects the infant.Scientific reports · 2019Article
- Foot-and-mouth disease in Southern Ghana: occurrence and molecular characterization of circulating viruses.Tropical animal health and production · 2019Article
- Reconstructing foot-and-mouth disease outbreaks: a methods comparison of transmission network models.Scientific reports · 2019Article
- Statistical outbreak detection by joining medical records and pathogen similarity.Journal of biomedical informatics · 2019Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to quantify the extent to which the genetic diversity of foot-and-mouth disease virus (FMDV) arising over the course of infection of an individual animal becomes fixed, is transmitted to other animals, and thereby accumulates over the course of an outbreak. Complete consensus sequences of 23 genomes (each of 8,200 nucleotides) of FMDV were recovered directly from epithelium tissue acquired from 21 farms infected over a nearly 7-month period during the 2001 FMDV outbreak in the United Kingdom. An analysis of these consensus sequences revealed very few apparently ambiguous sites but clear evidence of 197 nucleotide substitutions at 191 different sites. We estimated the rate of nucleotide substitution to be 2.26 x 10(-5) per site per day (95% confidence interval [CI], 1.75 x 10(-5) to 2.80 x 10(-5)) and nucleotide substitutions to accrue in the consensus sequence at an average rate of 1.5 substitutions per farm infection. This is a sufficiently high rate showing that detailed histories of the transmission pathways can be reliably reconstructed. Coalescent methods indicated that the date at which FMDV first infected livestock in the United Kingdom was 7 February 2001 (95% CI, 20 January to 19 February 2001), which was identical to estimates obtained on the basis of purely clinical evidence. Nucleotide changes appeared to have occurred evenly across the genome, and within the open reading frame, the ratio of nonsynonymous-to-synonymous change was 0.09. The ability to recover particular transmission pathways of acutely acting RNA pathogens from genetic data will help resolve uncertainties about how virus is spread and could help in the control of future epidemics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.