ArticleExperimental neurology2007
Chondroitinase applied to peripheral nerve repair averts retrograde axonal regeneration.
Article in Experimental neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- The Role of Length of Nerve Grafts in Combination with Free Functional Muscle Transplantation for Brachial Plexus Injury: A Single-Center Experience.Journal of personalized medicine · 2024Article
- The Heterogeneous Multiple Sclerosis Lesion: How Can We Assess and Modify a Degenerating Lesion?International journal of molecular sciences · 2023Review
- Repair of ovine peripheral nerve injuries with xenogeneic human acellular sciatic nerves prerecellularized with allogeneic Schwann-like cells-an innovative and promising approach.Regenerative therapy · 2022Article
- Clinical Outcomes of Symptomatic Neuroma Resection and Reconstruction with Processed Nerve Allograft.Plastic and reconstructive surgery. Global open · 2021Article
- Advances in the repair of segmental nerve injuries and trends in reconstruction.Muscle & nerve · 2020Review
- Glial Cell Line-Derived Neurotrophic Factor and Chondroitinase Promote Axonal Regeneration in a Chronic Denervation Animal Model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- IGF-1 and Chondroitinase ABC Augment Nerve Regeneration after Vascularized Composite Limb Allotransplantation.PloS one · 2016Article
- Article
- Tissue engineered constructs for peripheral nerve surgery.European surgery : ACA : Acta chirurgica Austriaca · 2013Article
- Synergistic effects of bone mesenchymal stem cells and chondroitinase ABC on nerve regeneration after acellular nerve allograft in rats.Cellular and molecular neurobiology · 2012Article
- Histomorphometric changes in repaired mouse sciatic nerves are unaffected by the application of a scar-reducing agent.Journal of anatomy · 2011Article
- Acellular nerve allografts in peripheral nerve regeneration: a comparative study.Muscle & nerve · 2011Article
- Rolipram-induced elevation of cAMP or chondroitinase ABC breakdown of inhibitory proteoglycans in the extracellular matrix promotes peripheral nerve regeneration.Experimental neurology · 2010Article
- Extracellular matrix remodelling in human diabetic neuropathy.Journal of anatomy · 2009Article
- Chondroitinase treatment increases the effective length of acellular nerve grafts.Experimental neurology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that may contribute to misdirection of axonal regrowth. In the present study, we tested the hypothesis that degradation of chondroitin sulfate proteoglycan by application of chondroitinase at the site of nerve repair can decrease aberrant axonal growth. Adult rats received bilateral sciatic nerve transection and end-to-end repair. One nerve was injected with chondroitinase ABC and the contralateral nerve treated with vehicle alone. After 28 weeks, retrograde axonal regeneration was assessed proximal to the repair by scoring neurofilament-immunopositive axons within the nerve (intrafascicular) and outside the nerve proper (extrafascicular). Intrafascicular retrograde axonal growth was equivalent in both control and chondroitinase treatment conditions. In contrast, chondroitinase treatment caused a pronounced (93%) reduction in extrafascicular retrograde axonal growth. The decrease in axon egress from the nerve was coincident with an increase in antegrade regeneration and improved recovery of motor function. Based on these findings, we conclude that chondroitinase applied at the site of nerve transection repair averts dysfunctional extrafascicular retrograde axonal growth.
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