ArticleExtremophiles : life under extreme conditions2007
HMG-CoA reductase is regulated by salinity at the level of transcription in Haloferax volcanii.
Article in Extremophiles : life under extreme conditions, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- A New Era for Using Natural Pigments: The Case of the CBiotechnology and applied biochemistry · 2026Review
- Microbial Bacterioruberin: A Comprehensive Review.Indian journal of microbiology · 2024Review
- Antioxidant Capacity of Carotenoid Extracts from the HaloarchaeonAntioxidants (Basel, Switzerland) · 2023Article
- Carbon Source Influences Antioxidant, Antiglycemic, and Antilipidemic Activities ofMarine drugs · 2022Article
- Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential.Marine drugs · 2022Review
- Article
- In Search for the Membrane Regulators of Archaea.International journal of molecular sciences · 2019Review
- Development of a plasmid free CRISPR-Cas9 system for the genetic modification of Mucor circinelloides.Scientific reports · 2017Article
- Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2017Review
- Carotenoid Production by Halophilic Archaea Under Different Culture Conditions.Current microbiology · 2016Review
- The Proteome and Lipidome of Thermococcus kodakarensis across the Stationary Phase.Archaea (Vancouver, B.C.) · 2016Article
- Carotenoids from Haloarchaea and Their Potential in Biotechnology.Marine drugs · 2015Review
- Phylogenetically driven sequencing of extremely halophilic archaea reveals strategies for static and dynamic osmo-response.PLoS genetics · 2014Article
- Transcription of the three HMG-CoA reductase genes of Mucor circinelloides.BMC microbiology · 2014Article
- Characterization of halophiles isolated from solar salterns in Baja California, Mexico.Extremophiles : life under extreme conditions · 2009Article
- Proteomic analysis of Haloferax volcanii reveals salinity-mediated regulation of the stress response protein PspA.Microbiology (Reading, England) · 2008Article
- HMG-CoA reductase is regulated by environmental salinity and its activity is essential for halotolerance in halophilic fungi.Studies in mycology · 2008Article
- Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature.Saline systems · 2007Article
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The moderately halophilic archaeon Haloferax volcanii was surveyed for protein profile changes correlated with growth at high and low salinity. A single polypeptide with an approximate mass of 46 kDa was conspicuously more abundant during growth at high salinity. This protein was identified as HMG-CoA reductase (HMGR), encoded by the hmgR gene. HMGR is a key enzyme in the mevalonate pathway of isoprenoid biosynthesis, the sole route in haloarchaea for lipid and carotenoid production. Enzymatic assays confirmed that HMGR activity is more abundant in cells grown at high salinity. Low salt cultures of H. volcanii contained lower amounts of hmgR transcript compared to cells grown in high salt suggesting that the observed regulation occurs at the level of transcription. Paradoxically, both lipid and carotenoid content decreased in H. volcanii grown at high salinity despite the increased levels of HMGR specific activity. To our knowledge, this is the first report demonstrating that the expression of HMGR is regulated in response to non-optimal salinity in a halophilic archaeon.
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