ReviewPharmaceutical research2007
Controlling protein compartmentalization to overcome disease.
Review in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- ProtLoc-GRPO: Cell line-specific subcellular localization prediction using a graph-based model and reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Comprehensive Prediction of Protein Localization and Signal Peptides Using MULocDeep.Methods in molecular biology (Clifton, N.J.) · 2025Article
- MULocDeep web service for protein localization prediction and visualization at subcellular and suborganellar levels.Nucleic acids research · 2023Article
- Protein Subcellular Localization Prediction Model Based on Graph Convolutional Network.Interdisciplinary sciences, computational life sciences · 2022Article
- Computational methods for protein localization prediction.Computational and structural biotechnology journal · 2021Review
- MULocDeep: A deep-learning framework for protein subcellular and suborganellar localization prediction with residue-level interpretation.Computational and structural biotechnology journal · 2021Article
- Multiple sequences orchestrate subcellular trafficking of neuronal PAS domain-containing protein 4 (NPAS4).The Journal of biological chemistry · 2018Article
- LocSigDB: a database of protein localization signals.Database : the journal of biological databases and curation · 2015Article
- Targeting nucleocytoplasmic transport in cancer therapy.Oncotarget · 2014Review
- Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.Molecular pharmaceutics · 2013Article
- The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2012Review
- Utilizing the estrogen receptor ligand-binding domain for controlled protein translocation to the insoluble fraction.Pharmaceutical research · 2012Article
- Optofluidic detection for cellular phenotyping.Lab on a chip · 2012Review
- Direct induction of apoptosis using an optimal mitochondrially targeted p53.Molecular pharmaceutics · 2012Article
- Nuclear export of proteins and drug resistance in cancer.Biochemical pharmacology · 2012Review
- Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.PloS one · 2012Article
- The androgen receptor and its use in biological assays: looking toward effect-based testing and its applications.Journal of analytical toxicology · 2011Review
- Transduction of human recombinant proteins into mitochondria as a protein therapeutic approach for mitochondrial disorders.Pharmaceutical research · 2011Review
- Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry.Lab on a chip · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Over the past decade, considerable progress has been made to improve our understanding of the intracellular transport of proteins. Mechanisms of nuclear import and export involving classical receptors have been studied. Signal sequences required for directing a protein molecule to a specific cellular compartment have been defined. Knowledge of subcellular trafficking of proteins has also increased our understanding of diseases caused due to mislocalization of proteins. A specific protein on deviating from its native cellular compartment may result in disease due to loss of its normal functioning and aberrant activity in the "wrong" compartment. Mislocalization of proteins results in diseases that range from metabolic disorders to cancer. In this review we discuss some of the diseases caused due to mislocalization. We further focus on application of nucleocytoplasmic transport to drug delivery. Various rationales to treat diseases by exploiting intracellular transport machinery have been proposed. Although the pathways for intracellular movement of proteins have been defined, these have not been adequately utilized for management of diseases involving mislocalized proteins. This review stresses the need for designing drug delivery systems utilizing these mechanisms as this area is least exploited but offers great potential.
Indexed as
Identifiers
16969692What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.