ArticleDiabetologia2006
The impact of family history of diabetes and lifestyle factors on abnormal glucose regulation in middle-aged Swedish men and women.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Exercise-Induced Improvements in Insulin Sensitivity Are Not Attenuated by a Family History of Type 2 Diabetes.Frontiers in endocrinology · 2020Trial
- Impact of positive family history and genetic risk variants on the incidence of diabetes: the Finnish Diabetes Prevention Study.Diabetes care · 2011Trial
- Observational study of selective screening for prediabetes and diabetes in a real-world setting: an interprofessional collaboration method between public dental services and primary health care in Sweden.Scandinavian journal of primary health care · 2024Observational
- Investigating family history of diabetes as a predictor of fasting insulin and fasting glucose activity in a sample of healthy weight adults.Acta diabetologica · 2023Article
- Cohort Profile: The Stockholm Diabetes Prevention Programme (SDPP).International journal of epidemiology · 2022Article
- Interaction analysis of lipid accumulation product and family history of diabetes on impaired fasting glucose and diabetes risk in population with normotension in Eastern China: a community-based cross-sectional survey.Archives of public health = Archives belges de sante publique · 2022Article
- Association between having a family member with dementia and perceptions of dementia preventability.Aging & mental health · 2022Article
- A Comparison of Nutritional Status, Knowledge and Type 2 Diabetes Risk Among Malaysian Young Adults With and Without Family History of Diabetes.The Malaysian journal of medical sciences : MJMS · 2021Article
- Article
- Association and Interaction Analysis of Lipid Accumulation Product with Impaired Fasting Glucose Risk: A Cross-Sectional Survey.Journal of diabetes research · 2019Article
- A Case-Control Study on Risk Factors and Their Interactions with Prediabetes among the Elderly in Rural Communities of Yiyang City, Hunan Province.Journal of diabetes research · 2019Article
- Association of Percentage Body Fat and Metabolic Health in Offspring of Patients with Cardiovascular Diseases.Scientific reports · 2018Article
- Sense of coherence, self-esteem, and health locus of control in subjects with type 1 diabetes mellitus with/without satisfactory metabolic control.Journal of endocrinological investigation · 2018Article
- Genetic variants of increased waist circumference in psychosis.Psychiatric genetics · 2017Article
- Indexing Natural Products for Their Potential Anti-Diabetic Activity: Filtering and Mapping Discriminative Physicochemical Properties.Molecules (Basel, Switzerland) · 2017Article
- Article
- Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016Article
- Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness.Diabetes · 2016Article
- Cannabis Use as Risk or Protection for Type 2 Diabetes: A Longitudinal Study of 18 000 Swedish Men and Women.Journal of diabetes research · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisWe investigated associations between abnormal glucose regulation and family history of diabetes, separately and in combination with lifestyle risk factors. SUBJECTS AND
methodsThis cross-sectional study comprised 3,128 men and 4,821 women, aged 35-56 years, half with a family history of diabetes. Oral glucose tolerance testing identified subjects with previously undiagnosed prediabetes (IFG, IGT) and type 2 diabetes. Information on lifestyle factors was obtained by questionnaire. Biological interaction was measured with the synergy index.
resultsA family history of diabetes conferred a higher odds ratio (OR) for type 2 diabetes in men (OR=3.1, 95% CI 1.7-5.6) than in women (OR=1.7, 95% CI 1.0-3.0), and the synergy index was 2.8 (95% CI 0.9-9.0), suggesting interaction between a family history of diabetes and sex. For prediabetes and diabetes combined, the synergy index was 1.7 (1.0-2.8). Exposure to only one lifestyle risk factor (obesity, physical inactivity, smoking or low sense of coherence [a psychosocial index]) increased the risk to a similar extent in men and women. Combined exposure to a family history of diabetes and lifestyle-related risk factors had a greater effect on type 2 diabetes than any of these factors alone, especially in men. However, analysis of interaction between a family history of diabetes and the lifestyle factors did not indicate any interaction for diabetes, but did indicate interaction for a family history of diabetes and obesity in women with prediabetes. CONCLUSIONS/
interpretationOur data suggest a more pronounced effect of a family history of diabetes on the risk of type 2 diabetes in men than in women. While both a family history of diabetes and lifestyle risk factors had effects on type 2 diabetes, irrespective of sex, these effects did not appear to interact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.