ArticleDiabetologia2006
The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 84 citations in OpenAlex.
- CX3CR1-T280M polymorphism and end-stage renal disease development in chronic kidney disease.Scientific reports · 2026Observational
- The association of RAGE gene polymorphisms with inflammatory and oxidative stress markers in diabetic kidney disease patients.Molecular biology reports · 2025Article
- Rage gene -374T/A polymorphism in South Indian diabetic nephropathy.Bioinformation · 2025Article
- Genetics of diabetes-associated microvascular complications.Diabetologia · 2023Review
- Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?-a review.Journal, genetic engineering & biotechnology · 2022Review
- Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World.Genes · 2021Review
- Polymorphisms of the receptor for advanced glycation end products as vasculopathy predictor in sickle cell disease.Pediatric research · 2021Article
- Pathological Implications of Receptor for Advanced Glycation End-Product (Disease markers · 2019Review
- A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.Acta ophthalmologica · 2018Article
- HLA and kidney disease: from associations to mechanisms.Nature reviews. Nephrology · 2018Review
- Association of single-nucleotide polymorphisms in theOncotarget · 2017Article
- Candidate gene studies of diabetic retinopathy in human.Molecular biology reports · 2016Review
- Polymorphism 2184A/G in the AGER gene is not associated with diabetic retinopathy in Han Chinese patients with type 2 diabetes.The Journal of international medical research · 2016Article
- Article
- Human genetics of diabetic retinopathy.Journal of endocrinological investigation · 2014Review
- Genetics of diabetes complications.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Association of polymorphisms of the receptor for advanced glycation end products gene with COPD in the Chinese population.DNA and cell biology · 2014Article
- Challenges in elucidating the genetics of diabetic retinopathy.JAMA ophthalmology · 2014Review
- Human genetics of diabetic vascular complications.Journal of genetics · 2013Review
- Genetics in diabetic retinopathy: current concepts and new insights.Current genomics · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe receptor for AGE (RAGE) is considered to be mainly an intracellular signal-transducer or pro-inflammatory peptide of possible importance for inflammation and autoimmune diseases. Our aim was to study whether the -374 T/A polymorphism in the gene encoding RAGE (AGER) is associated with diabetes type and presence of diabetic complications.
methodsThe AGER -374 T/A polymorphism was genotyped in 867 type 1 diabetic patients, 2,467 type 2 diabetic patients and 205 non-diabetic control subjects of Scandinavian origin.
resultsAGER polymorphism was related to different HLA-DQB1 genotypes and the presence of diabetic complications. Type 1 diabetic patients had a higher frequency of the AGER -374 A/A or T/A genotypes than type 2 diabetic patients (51.1 vs 44.9%, p=0.002) and control subjects (51.1 vs 47.6%, p=0.0006). The RAGE -374 T/A polymorphism was associated with HLA-DQB1 genotypes; patients with HLA risk genotypes had a higher frequency of the A/A or T/A genotypes than patients with other HLA-DQB1 genotypes (60.3 vs 40.3%, p<0.000001). In type 1 diabetic patients, the frequency of the A/A or T/A genotypes was higher in patients with diabetic nephropathy than without (61.1 vs 46.8%, p=0.006) and with sight-threatening retinopathy than without (56.1 vs 47.6%, p=0.03). In type 2 diabetic patients with HbA(1c) values below the median, the T/T genotype was more frequent in patients with diabetic nephropathy than without (54.3 vs 38.2%, p=0.02). CONCLUSIONS/
interpretationOur results show an association between the AGER -374 T/A polymorphism and type 1 diabetes. This association was HLA-DQB1-dependent. The polymorphism was associated with diabetic nephropathy in both type 1 and type 2 diabetes, in an HbA(1c)-dependent manner in the latter group, and also with sight-threatening retinopathy in type 1 diabetic patients.
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