ArticleJournal of neural transmission (Vienna, Austria : 1996)2007
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Folate and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2021Pooled it
- Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration.Frontiers in neurology · 2019Article
- Biothiols and oxidative stress markers and polymorphisms ofOncotarget · 2018Article
- Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations.Open biology · 2018Review
- Review
- The effects of beta-endorphin: state change modification.Fluids and barriers of the CNS · 2015Review
- Article
- Reciprocal modulation of Aβ42 aggregation by copper and homocysteine.Frontiers in aging neuroscience · 2014Article
- Cycling of dense core vesicles involved in somatic exocytosis of serotonin by leech neurons.Frontiers in physiology · 2012Article
- Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?Trends in pharmacological sciences · 2011Review
- A window into the heterogeneity of human cerebrospinal fluid Aβ peptides.Journal of biomedicine & biotechnology · 2011Review
- Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment.Neuromolecular medicine · 2010Article
- Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats.Indian journal of pharmacology · 2010Article
- Cobalamin deficiency, hyperhomocysteinemia, and dementia.Neuropsychiatric disease and treatment · 2010Article
- Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Almond for mild to moderate Alzheimer's disease: A randomized clinical trial.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid peptides (Abeta) can operate as volume transmission (VT) signals since they are continuously released from cells of the central nervous system and diffuse in the extra-cellular space of the brain. They have both regulatory and trophic functions on cellular networks. In agreement with Abeta regulatory actions on glial-neuronal networks, the present paper reports new findings demonstrating that intrastriatal injections of Abeta peptides reduce striatal tyrosine hydroxylase, increase striatal GFAP immunoreactivities and lower pain threshold in experimental rats. Furthermore, it has been demonstrated that exogenous homocysteine (Hcy) binds Abeta(1-40) favouring its beta-sheet conformation both in vitro and in vivo and hence the formation of beta-fibrils and development of neurotoxicity. Thus, the hypothesis is discussed that Abeta peptides represent crucial VT-signals in the brain and their action is altered by dysmetabolic signals such as high Hcy extra-cellular levels, known to be an important risk factor for Alzheimer's disease.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.