Evidence map›Paper›PMID 16969364›Full record

ReviewThe pharmacogenomics journal2007

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.

G D Leschziner, T Andrew, M Pirmohamed, M R Johnson

Abstract readReview
PubMed Publisher
In one paragraph

Review in The pharmacogenomics journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 3 syntheses or guidelines pooled it, 300 citations in OpenAlex.

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  11. Pediatric reports · 2025
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  19. Common P-glycoprotein (Biochemia medica · 2024
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

G D LeschzinerDivision of Neurosciences, Imperial College, London, UK. gl1@sanger.ac.uk
T Andrew
M Pirmohamed
M R Johnson
Imperial College London · GBUniversity of Liverpool · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The product of the ABCB1 gene, P-glycoprotein (PGP), is a transmembrane active efflux pump for a variety of drugs. It is a putative mechanism of multidrug resistance in a range of diseases. It is postulated that ABCB1 polymorphisms contribute to variability in PGP function, and that therefore multidrug resistance is, at least in part, genetically determined. However, studies of ABCB1 genotype or haplotype and PGP expression, activity or drug response have produced inconsistent results. This critical review of ABCB1 genotype and PGP function, including mRNA expression, PGP-substrate drug pharmacokinetics and drug response, highlights methodological limitations of existing studies, including inadequate power, potential confounding by co-morbidity and co-medication, multiple testing, poor definition of disease phenotype and outcomes, and analysis of multiple drugs that might not be PGP substrates. We have produced recommendations for future research that will aid clarification of the association between ABCB1 genotypes and factors related to PGP activity.

Indexed as

AnimalsAntidepressive AgentsAnti-HIV AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1CD4 Lymphocyte CountDigoxinEpilepsyGenotypeHaplotypesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsImmunosuppressive AgentsKidneyNeoplasmsOrganic Anion TransportersABCB1 protein, humanAntidepressive AgentsAnti-HIV AgentsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1DigoxinHydroxymethylglutaryl-CoA Reductase InhibitorsImmunosuppressive AgentsOrganic Anion TransportersRNA, Messenger

Identifiers

PMID16969364
OpenAlexW2000357710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.