ArticleMolecular systems biology2006
When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation.
Article in Molecular systems biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 217 citations in OpenAlex.
- Energy-translation coupling limits anaerobic yeast growth.Nature communications · 2026Article
- Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.Molecular biology of the cell · 2026Article
- Engineering energy-efficient Saccharomyces cerevisiae for methanol and CONature communications · 2026Article
- Non-redundant roles for paralogous proteins in the yeast glucose-sensing pathway.bioRxiv : the preprint server for biology · 2025Article
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- Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors.Microbial biotechnology · 2023Article
- Monitoring Intracellular Metabolite Dynamics inMetabolites · 2022Article
- High-throughput metabolomics predicts drug-target relationships for eukaryotic proteins.Molecular systems biology · 2022Article
- Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast.Biomolecules · 2022Article
- Kinetic Modeling ofMetabolites · 2022Review
- Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1.PLoS genetics · 2021Article
- Dynamic control in metabolic engineering: Theories, tools, and applications.Metabolic engineering · 2021Review
- Pbp1, the yeast ortholog of human Ataxin-2, functions in the cell growth on non-fermentable carbon sources.PloS one · 2021Article
- Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.Science advances · 2020Article
- The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown upon glucose availability.The Journal of biological chemistry · 2019Article
- Systematic identification of metabolites controlling gene expression in E. coli.Nature communications · 2019Article
- Metabolic switches from quiescence to growth in synchronized Saccharomyces cerevisiae.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- A fast and tuneable auxin-inducible degron for depletion of target proteins in budding yeast.Yeast (Chichester, England) · 2019Article
- Quantitative Flow Cytometry to Understand Population Heterogeneity in Response to Changes in Substrate Availability inFrontiers in bioengineering and biotechnology · 2019Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within the first 5 min after a sudden relief from glucose limitation, Saccharomyces cerevisiae exhibited fast changes of intracellular metabolite levels and a major transcriptional reprogramming. Integration of transcriptome and metabolome data revealed tight relationships between the changes at these two levels. Transcriptome as well as metabolite changes reflected a major investment in two processes: adaptation from fully respiratory to respiro-fermentative metabolism and preparation for growth acceleration. At the metabolite level, a severe drop of the AXP pools directly after glucose addition was not accompanied by any of the other three NXP. To counterbalance this loss, purine biosynthesis and salvage pathways were transcriptionally upregulated in a concerted manner, reflecting a sudden increase of the purine demand. The short-term dynamics of the transcriptome revealed a remarkably fast decrease in the average half-life of downregulated genes. This acceleration of mRNA decay can be interpreted both as an additional nucleotide salvage pathway and an additional level of glucose-induced regulation of gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.