ArticleThe Korean journal of parasitology2006
Involvement of MAPK activation in chemokine or COX-2 productions by Toxoplasma gondii.
Article in The Korean journal of parasitology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The roles of COX-2 in protozoan infection.Frontiers in immunology · 2023Review
- Inhibitory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- IncreasedFrontiers in microbiology · 2019Article
- Cyclooxygenase (COX)-2 Inhibitors ReduceFrontiers in microbiology · 2019Article
- A Human Proteome Array Approach to Identifying Key Host Proteins Targeted byMolecular & cellular proteomics : MCP · 2017Article
- Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity.Infection and immunity · 2016Article
- Transcriptional Regulation of CXCL5 in HIV-1-Infected Macrophages and Its Functional Consequences on CNS Pathology.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Article
- Differential regulation of proinflammatory cytokine expression by mitogen-activated protein kinases in macrophages in response to intestinal parasite infection.Infection and immunity · 2014Article
- Recurrent headaches may be caused by cerebral toxoplasmosis.World journal of clinical pediatrics · 2014Article
- Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells.PloS one · 2011Article
- Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor.Infection and immunity · 2008Article
- Monocyte-mediated defense against microbial pathogens.Annual review of immunology · 2008Review
- Several transcription factors regulate COX-2 gene expression in pancreatic beta-cells.Molecular biology reports · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This experiment focused on MAPK activation in host cell invasion and replication of T. gondii, as well as the expression of CC chemokines, MCP-1 and MIP-1 alpha , and enzyme, COX-2/prostaglandin E2 (PGE2) in infected cells via western blot, [3H]-uracil incorporation assay, ELISA and RT-PCR. The phosphorylation of ERK1/2 and p38 in infected HeLa cells was detected at 1 hr and/or 6 hr postinfection (PI). Tachyzoite proliferation was reduced by p38 or JNK MAPK inhibitors. MCP-1 secretion was enhanced in infected peritoneal macrophages at 6 hr PI. MIP-1 alpha mRNA was increased in macrophages at 18 hr PI. MCP-1 and MIP-1 alpha were reduced after treatment with inhibitors of ERK1/2 and JNK MAPKs. COX-2 mRNA gradually increased in infected RAW 264.7 cells and the secretion of COX-2 peaked at 6 hr PI. The inhibitor of JNK suppressed COX-2 expression. PGE2 from infected RAW 264.7 cells was increased and synthesis was suppressed by PD98059, SB203580, and SP600125. In this study, the activation of p38, JNK and/or ERK1/2 MAPKs occurred during the invasion and proliferation of T. gondii tachyzoites in HeLa cells. Also, increased secretion and expression of MCP-1, MIP-1 alpha , COX-2 and PGE2 were detected in infected macrophages, and appeared to occur via MAPK signaling pathways.
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