ArticlePLoS biology2006
Initiation, establishment, and maintenance of heritable MuDR transposon silencing in maize are mediated by distinct factors.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 100 citations in OpenAlex.
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- Structure and RNA template requirements ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- RNA-directed DNA methylation prevents rapid and heritable reversal of transposon silencing under heat stress in Zea mays.PLoS genetics · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Silencing ofGenetics · 2020Article
- S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression.Cell reports · 2020Article
- Epigenetic Regulation of ABA-Induced Transcriptional Responses in Maize.G3 (Bethesda, Md.) · 2020Article
- The Role of Transposable Elements in Speciation.Genes · 2018Review
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- Angiosperms Are Unique among Land Plant Lineages in the Occurrence of Key Genes in the RNA-Directed DNA Methylation (RdDM) Pathway.Genome biology and evolution · 2015Article
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- Accessible DNA and relative depletion of H3K9me2 at maize loci undergoing RNA-directed DNA methylation.The Plant cell · 2014Article
- Chromatin structure and gene expression changes associated with loss of MOP1 activity in Zea mays.Epigenetics · 2014Article
- Three groups of transposable elements with contrasting copy number dynamics and host responses in the maize (Zea mays ssp. mays) genome.PLoS genetics · 2014Article
- CHH islands: de novo DNA methylation in near-gene chromatin regulation in maize.Genome research · 2013Article
- Maize RNA polymerase IV defines trans-generational epigenetic variation.The Plant cell · 2013Article
- required to maintain repression2 is a novel protein that facilitates locus-specific paramutation in maize.The Plant cell · 2012Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Paramutation and transposon silencing are two epigenetic phenomena that have intrigued and puzzled geneticists for decades. Each involves heritable changes in gene activity without changes in DNA sequence. Here we report the cloning of a gene whose activity is required for the maintenance of both silenced transposons and paramutated color genes in maize. We show that this gene, Mop1 (Mediator of paramutation1) codes for a putative RNA-dependent RNA polymerase, whose activity is required for the production of small RNAs that correspond to the MuDR transposon sequence. We also demonstrate that although Mop1 is required to maintain MuDR methylation and silencing, it is not required for the initiation of heritable silencing. In contrast, we present evidence that a reduction in the transcript level of a maize homolog of the nucleosome assembly protein 1 histone chaperone can reduce the heritability of MuDR silencing. Together, these data suggest that the establishment and maintenance of MuDR silencing have distinct requirements.
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