ArticleMarine biotechnology (New York, N.Y.)
Heavy metal-induced differential gene expression of metallothionein in Javanese medaka, Oryzias javanicus.
Article in Marine biotechnology (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 78 citations in OpenAlex.
- Long-term chromium exposure and its residual impact on growth, biochemical changes and immune gene expression of climbing perch (Anabas testudineus).Journal of fish biology · 2026Article
- mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated withWorld journal of hepatology · 2023Article
- Detection of Metallothionein in Javanese Medaka (Oryzias javanicus), Using a scFv-Immobilized Protein Chip.Sensors (Basel, Switzerland) · 2018Article
- Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride.International journal of molecular sciences · 2017Article
- Transcriptome response to copper heavy metal stress in hard-shelled mussel (Mytilus coruscus).Genomics data · 2016Article
- Article
- Radiation-induced bystander effects in the Atlantic salmon (salmo salar L.) following mixed exposure to copper and aluminum combined with low-dose gamma radiation.Radiation and environmental biophysics · 2014Article
- Transcriptional changes caused by bisphenol A in Oryzias javanicus, a fish species highly adaptable to environmental salinity.Marine drugs · 2014Article
- Transcription patterns of genes encoding four metallothionein homologs in Daphnia pulex exposed to copper and cadmium are time- and homolog-dependent.Aquatic toxicology (Amsterdam, Netherlands) · 2013Article
- The yellow catfish, Pelteobagrus fulvidraco (Siluriformes) metallothionein cDNA: molecular cloning and transcript expression level in response to exposure to the heavy metals Cd, Cu, and Zn.Fish physiology and biochemistry · 2012Article
- Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel.Journal of nanobiotechnology · 2012Article
- Functional characterization of four metallothionein genes in Daphnia pulex exposed to environmental stressors.Aquatic toxicology (Amsterdam, Netherlands) · 2012Article
- Effect of cadmium on glutathione S-transferase and metallothionein gene expression in coho salmon liver, gill and olfactory tissues.Aquatic toxicology (Amsterdam, Netherlands) · 2012Article
- Anti-proliferative activity of silver nanoparticles.BMC cell biology · 2009Article
- Can thiol compounds be used as biomarkers of aquatic ecosystem contamination by cadmium?Interdisciplinary toxicology · 2009Article
- Non-linear effects in the formation of DNA damage in medaka fish fibroblast cells caused by combined action of cadmium and ionizing radiation.Dose-response : a publication of International Hormesis Society · 2008Article
- Identification of softness syndrome-associated candidate genes and DNA sequence variation in the sea squirt, Halocynthia roretzi.Marine biotechnology (New York, N.Y.)Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A metallothionein (MT) gene was isolated for the first time from Javanese medaka, Oryzias javanicus, which shows high adaptability from freshwater to seawater. The full-length cDNA of MT from O. javanicus (OjaMT) comprises 349 bp, excluding the poly(A)+ stretch, and codes for a total of 60 amino acids. The positions of cysteine residues are highly conserved. The pattern of OjaMT expression induced by six heavy metals was analyzed via real-time quantitative polymerase chain reaction (PCR). The level of hepatic OjaMT mRNA was increased in a dose-dependent manner by Ag, Cd, Cu, and Zn after 24 h of exposure. However, after Cr and Ni exposure, a significant decrease in OjaMT levels was observed. Cadmium-induced OjaMT expression was detectable in fishes as young as 3 months. After Cd exposure, OjaMT induction was prominent in intestine and liver and moderate in muscle and gill. OjaMT mRNA levels could represent a good biomarker for monitoring heavy metals in seawater.
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