ArticleProceedings of the National Academy of Sciences of the United States of America1990
Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic protist Trichomonas vaginalis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 105 citations in OpenAlex.
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- CRISPR/Cas9-mediated gene modification and gene knock out in the human-infective parasite Trichomonas vaginalis.Scientific reports · 2018Article
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes.International journal for parasitology · 2011Article
- Mitochondrion-related organelles in eukaryotic protists.Annual review of microbiology · 2010Review
- Molecular dynamics simulations of Trichomonas vaginalis ferredoxin show a loop-cap transition.Biophysical journal · 2007Article
- Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.Clinical microbiology reviews · 2007Review
- Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica.Eukaryotic cell · 2002Article
- A spliceosomal intron in Giardia lamblia.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Hydrogenases and hydrogen metabolism of cyanobacteria.Microbiology and molecular biology reviews : MMBR · 2002Review
- Presence of a member of the mitochondrial carrier family in hydrogenosomes: conservation of membrane-targeting pathways between hydrogenosomes and mitochondria.Molecular and cellular biology · 2000Article
- Why metronidazole is active against both bacteria and parasites.Antimicrobial agents and chemotherapy · 1999Review
- Clinical and microbiological aspects of Trichomonas vaginalis.Clinical microbiology reviews · 1998Review
- Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import.The EMBO journal · 1997Article
- Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica.Journal of bacteriology · 1997Article
- Transient and selectable transformation of the parasitic protist Trichomonas vaginalis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Presence of a mitochondrial-type 70-kDa heat shock protein in Trichomonas vaginalis suggests a very early mitochondrial endosymbiosis in eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A common evolutionary origin for mitochondria and hydrogenosomes.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Electrostatic effects in electron transfer reactions of [2Fe-2S] ferredoxins with inorganic reagents.Protein science : a publication of the Protein Society · 1996Article
- Primary structure and eubacterial relationships of the pyruvate:ferredoxin oxidoreductase of the amitochondriate eukaryote Trichomonas vaginalis.Journal of molecular evolution · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have determined the primary structure of the [2Fe-2S]ferredoxin of the anaerobic protist Trichomonas vaginalis. This protein, situated in the hydrogenosome, is composed of 93 amino acids. A comparison of T. vaginalis ferredoxin with greater than 80 other ferredoxins shows the closest similarity to [2Fe-2S]putidaredoxin of the aerobic bacterium Pseudomonas putida and a lesser one to mitochondrial [2Fe-2S]ferredoxins of vertebrates. This similarity is reflected in the overall primary structure and in the spacing of cysteine residues coordinating the iron-sulfur center. The primary structure, but not the environment of the iron-sulfur center, also shows similarity with [2Fe-2S]ferredoxins of photosynthetic organisms and halobacteria. We have cloned and analyzed the T. vaginalis ferredoxin gene. The gene is present in a single copy and devoid of introns. It gives rise to a transcript with unusually short 5' and 3' untranslated regions of 16 and 18 nucleotides, respectively. DNA sequence analysis of the gene predicts an additional 8 amino acids at the amino terminus which are absent from the purified protein. This amino-terminal region of the protein is characterized by properties typical of mitochondrial presequences.
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