ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2006
Incidence and causes of severe neonatal hyperbilirubinemia in Canada.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 6 of them syntheses that pooled it.
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105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 327 citations in OpenAlex.
- Transcutaneous bilirubinometry for detecting jaundice in term or late preterm neonates.The Cochrane database of systematic reviews · 2024Pooled it
- Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns.The Cochrane database of systematic reviews · 2023Pooled it
- Etiology and therapeutic management of neonatal jaundice in Iran: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020Pooled it
- Prevalence of neonatal hyperbilirubinaemia and its association with glucose-6-phosphate dehydrogenase deficiency and blood-type incompatibility in sub-Saharan Africa: a systematic review and meta-analysis.BMJ paediatrics open · 2020Pooled it
- Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis.Pharmaceutical biology · 2017Pooled it
- Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels.Pediatric research · 2013Pooled it
- Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.Scientific reports · 2022Trial
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- Neonates admitted to the neonatal intensive care unit following pediatric emergency department visits in Türkiye: a retrospective single-center study.BMC pediatrics · 2026Article
- Phototherapy, Morbidity, and Mortality in Very Preterm Newborns.JAMA network open · 2026Article
- Comparison of bilirubin albumin ratio and total serum bilirubin for predicting neurological dysfunction in newborns: A meta-analysis.World journal of clinical pediatrics · 2026Article
- Design and Photometric Optimization of a Low-Cost Phototherapy Bed for Neonatal Jaundice.Annals of biomedical engineering · 2026Article
- Comparing Neurodevelopmental Outcome among Neonates with Jaundice Due to ABO and Rh Incompatibility.Iranian journal of child neurology · 2026Article
- Incidence and risk factors for neonatal jaundice in a teaching hospital in Northern Ghana.BMC pediatrics · 2025Article
- Severe neonatal hyperbilirubinemia in infants aged 60 days or less (2025 to 2027).Paediatrics & child health · 2025Article
- Establishing a mathematical standard model for calculating the volume of peripheral arteriovenous synchronous blood exchange transfusion in neonates with severe hyperbilirubinemia.Pakistan journal of medical sciences · 2025Article
- Cumulative Ambient Light Exposure Affects Outpatient Transcutaneous Bilirubinometer Readings.Children (Basel, Switzerland) · 2025Article
- Controversies in our understanding of extreme hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient neonates.Pediatric research · 2025Review
- Exchange Transfusion Trends and Risk Factors for Extreme Neonatal Hyperbilirubinemia over 10 Years in Shiraz, Iran.Iranian journal of medical sciences · 2024Article
- Forgoing Exchange Transfusion in Neonatal Hyperbilirubinemia: A Single-Center Retrospective Cohort Study.Cureus · 2024Article
45 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere hyperbilirubinemia is the most common cause of neonatal readmission to hospital in Canada even though, in the majority of cases, risk factors can be identified before discharge. Severe neonatal hyperbilirubinemia and kernicterus continue to be reported worldwide in otherwise healthy term infants. We conducted this study to estimate the incidence of severe neonatal hyperbilirubinemia in Canada and to determine underlying causes, improved knowledge of which would be valuable to help identify strategies for risk reduction.
methodsData on term infants 60 days of age and younger with unconjugated hyperbilirubinemia were collected prospectively through the Canadian Paediatric Surveillance Program from 2002 to 2004. Infants were included if they had a peak serum total bilirubin level of more than 425 micromol/L or underwent an exchange transfusion. Infants with rhesus iso-immunization or who were born at less than 36 weeks' gestation were excluded.
resultsOf 367 cases reported, 258 were confirmed to be severe neonatal hyperbilirubinemia, for an estimated incidence of 1 in 2480 live births. Causes were identified in 93 cases and included ABO incompatibility (n = 48), glucose-6-phosphate dehydrogenase deficiency (n = 20), other antibody incompatibility (n = 12) and hereditary spherocytosis (n = 7). The mean peak bilirubin level reported was 471 micromol/L (standard deviation [SD] 76 micromol/L, range 156-841 micromol/L). Fifty-seven infants (22.1%) underwent an exchange transfusion. A total of 185 infants (71.7%) were readmitted to hospital, 121 (65.4%) of them within 5 days of age.
interpretationSevere neonatal hyperbilirubinemia continues to occur frequently in Canada. In the majority of cases, the underlying cause was not identified. The high readmission rate within days after initial discharge indicates a need for a more thorough assessment of newborn infants and consideration of strategies to identify at-risk newborns, such as predischarge measurement of serum bilirubin levels.
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