Evidence map›Paper›PMID 16966547›Full record

ArticleNeurology2006

Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.

A J Saykin, H A Wishart, L A Rabin, R B Santulli, L A Flashman, J D West, T L McHugh, A C Mamourian

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 5 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 5 syntheses or guidelines pooled it, 584 citations in OpenAlex.

  1. Pooled it
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  6. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
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  7. Subjective cognition and mood in persistent chemotherapy-related cognitive impairment.Journal of cancer survivorship : research and practice · 2022
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  10. Nicotinic treatment of post-chemotherapy subjective cognitive impairment: a pilot study.Journal of cancer survivorship : research and practice · 2019
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256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A J SaykinBrain Imaging Laboratory, Department of Psychiatry, Dartmouth Medical School, Hanover, NH, USA. andrew.saykin@dartmouth.edu
H A Wishart
L A Rabin
R B Santulli
L A Flashman
J D West
T L McHugh
A C Mamourian
Dartmouth College · US

Funding

Washington University ConsoritumU54EB005149 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON · 2004 to 2013
$39.3M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI FOROUD, TATIANA M. · 1991 to 2020
$37.3M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG19771NIBIB NIH HHS U54 EB005149
6 · The paper itself

Abstract

objectiveTo examine the neural basis of cognitive complaints in healthy older adults in the absence of memory impairment and to determine whether there are medial temporal lobe (MTL) gray matter (GM) changes as reported in Alzheimer disease (AD) and amnestic mild cognitive impairment (MCI).

methodsParticipants were 40 euthymic individuals with cognitive complaints (CCs) who had normal neuropsychological test performance. The authors compared their structural brain MRI scans to those of 40 patients with amnestic MCI and 40 healthy controls (HCs) using voxel-based morphometry and hippocampal volume analysis.

resultsThe CC and MCI groups showed similar patterns of decreased GM relative to the HC group on whole brain analysis, with differences evident in the MTL, frontotemporal, and other neocortical regions. The degree of GM loss was associated with extent of both memory complaints and performance deficits. Manually segmented hippocampal volumes, adjusted for age and intracranial volume, were significantly reduced only in the MCI group, with the CC group showing an intermediate level.

conclusionsCognitive complaints in older adults may indicate underlying neurodegenerative changes even when unaccompanied by deficits on formal testing. The cognitive complaint group may represent a pre-mild cognitive impairment stage and may provide an earlier therapeutic opportunity than mild cognitive impairment. MRI analysis approaches incorporating signal intensity may have greater sensitivity in early preclinical stages than volumetric methods.

Indexed as

AgedAged, 80 and overAgingAnalysis of VarianceAtrophyBrain MappingFemaleHippocampusHumansMagnetic Resonance ImagingMaleMemory DisordersNeuropsychological TestsVerbal Learning

Identifiers

PMID16966547
PMCPMC3488276
OpenAlexW2012582740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.