ArticleInfection and immunity2006
Use of protein microarrays to define the humoral immune response in leprosy patients and identification of disease-state-specific antigenic profiles.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Analysis of antigens of Mycobacterium leprae by interaction to sera IgG, IgM, and IgA response to improve diagnosis of leprosy.BioMed research international · 2014Review
- Antibody profiling with protein antigen microarrays in early stage cancer.Expert opinion on medical diagnostics · 2012Article
- Lateral flow assay for simultaneous detection of cellular- and humoral immune responses.Clinical biochemistry · 2011Article
- ML1419c peptide immunization induces Mycobacterium leprae-specific HLA-A*0201-restricted CTL in vivo with potential to kill live mycobacteria.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Plasmodium immunomics.International journal for parasitology · 2011Review
- Early antibody response against Mycobacterium avium subspecies paratuberculosis antigens in subclinical cattle.Proteome science · 2008Article
- Peptide conformations for a microarray surface-tethered epitope of the tumor suppressor p53.The journal of physical chemistry. B · 2007Article
- Microarrays in infection and immunity.Current opinion in chemical biology · 2007Review
- [Protein arrays and perspectives of medical applications].Ingenierie et recherche biomedicale : IRBM = Biomedical engineering and researchReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Although the global prevalence of leprosy has decreased over the last few decades due to an effective multidrug regimen, large numbers of new cases are still being reported, raising questions as to the ability to identify patients likely to spread disease and the effects of chemotherapy on the overall incidence of leprosy. This can partially be attributed to the lack of diagnostic markers for different clinical states of the disease and the consequent implementation of differential, optimal drug therapeutic strategies. Accordingly, comparative bioinformatics and Mycobacterium leprae protein microarrays were applied to investigate whether leprosy patients with different clinical forms of the disease can be categorized based on differential humoral immune response patterns. Evaluation of sera from 20 clinically diagnosed leprosy patients using native protein and recombinant protein microarrays revealed unique disease-specific, humoral reactivity patterns. Statistical analysis of the serological patterns yielded distinct groups that correlated with phenolic glycolipid I reactivity and clinical diagnosis, thus demonstrating that leprosy patients, including those diagnosed with the paucibacillary, tuberculoid form of disease, can be classified based on humoral reactivity to a subset of M. leprae protein antigens produced in recombinant form.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.