ArticleInfection and immunity2006
Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- CD73 Expression by CD4Immunology · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells.PLoS pathogens · 2025Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes.Frontiers in immunology · 2018Review
- TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis.PLoS pathogens · 2017Article
- Salmonella as a model for non-cognate Th1 cell stimulation.Frontiers in immunology · 2014Review
- Perforin plays an unexpected role in regulating T-cell contraction during prolonged Listeria monocytogenes infection.European journal of immunology · 2012Article
- Anti-gamma interferon antibodies enhance the immunogenicity of recombinant adenovirus vectors.Clinical and vaccine immunology : CVI · 2011Article
- Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection.The Journal of experimental medicine · 2011Article
- Review
- Regulation of CD4+ T-cell contraction during pathogen challenge.Immunological reviews · 2010Review
- Role of PD-1 in regulating acute infections.Current opinion in immunology · 2010Review
- Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection.Infection and immunity · 2009Article
- IL-7 receptor expression provides the potential for long-term survival of both CD62Lhigh central memory T cells and Th1 effector cells during Leishmania major infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Surviving the crash: transitioning from effector to memory CD8+ T cell.Seminars in immunology · 2009Review
- Intrinsic and extrinsic control of effector T cell survival and memory T cell development.Immunologic research · 2009Review
- CD4 memory T cells divide poorly in response to antigen because of their cytokine profile.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Deviation from a strong Th1-dominated to a modest Th17-dominated CD4 T cell response in the absence of IL-12p40 and type I IFNs sustains protective CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Several lines of evidence from different model systems suggest that gamma interferon (IFN-gamma) is an important regulator of T-cell contraction after antigen (Ag)-driven expansion. To specifically investigate the role of IFN-gamma in regulating the contraction of Ag-specific CD4 T cells, we infected IFN-gamma-/- and IFN-gammaR1-/- mice with attenuated Listeria monocytogenes and monitored the numbers of Ag-specific CD4 T cells during the expansion, contraction, and memory phases of the immune response to infection. In the absence of IFN-gamma or the ligand-binding portion of its receptor, Ag-specific CD4 T cells exhibited normal expansion in numbers, but in both strains of deficient mice there was very little decrease in the number of Ag-specific CD4 T cells even at time points later than day 90 after infection. This significant delay in contraction was not due to prolonged infection, since mice treated with antibiotics to conclusively eliminate infection exhibited the same defect in contraction. In addition to altering the number of Ag-specific CD4 T cells, the absence of IFN-gamma signaling also changed the phenotype of cells generated after infection. IFN-gammaR1-/- Ag-specific CD4 T cells reacquired expression of CD127 more quickly than wild-type cells, and more IFN-gammaR1-/- CD4 T cells were capable of producing both IFN-gamma and interleukin 2 following Ag stimulation. From these data we conclude that IFN-gamma regulates the contraction, phenotype, and function of Ag-specific CD4 T cells generated after infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.