ArticleMolecular and cellular biology2006
O-GlcNAc integrates the proteasome and transcriptome to regulate nuclear hormone receptors.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- O-GlcNAcylation in Endocrinology: The Sweet Link.Endocrinology · 2025Review
- GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer.Science advances · 2021Article
- O-GlcNAc impairs endothelial function in uterine arteries from virgin but not pregnant rats: The role of GSK3β.European journal of pharmacology · 2020Article
- Article
- New Insights Into the Biology of Protein O-GlcNAcylation: Approaches and Observations.Frontiers in aging · 2020Article
- O-GlcNAcylation in women's cancers: breast, endometrial and ovarian.Journal of bioenergetics and biomembranes · 2018Review
- O-GlcNAc-Dependent Regulation of Progesterone Receptor Function in Breast Cancer.Hormones & cancer · 2018Article
- Protein O-GlcNAc Modification Increases in White Blood Cells After a Single Bout of Physical Exercise.Frontiers in immunology · 2018Article
- O-GlcNAc transferase is critical for transducin-like enhancer of split (TLE)-mediated repression of canonical Wnt signaling.The Journal of biological chemistry · 2014Article
- Three Decades of Research on O-GlcNAcylation - A Major Nutrient Sensor That Regulates Signaling, Transcription and Cellular Metabolism.Frontiers in endocrinology · 2014Review
- Immediate effects of a single exercise bout on protein O-GlcNAcylation and chromatin regulation of cardiac hypertrophy.American journal of physiology. Heart and circulatory physiology · 2013Article
- Post-translational protein modification by O-linked N-acetyl-glucosamine: its role in mediating the adverse effects of diabetes on the heart.Life sciences · 2013Review
- Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics.American journal of physiology. Heart and circulatory physiology · 2012Review
- Article
- Muscle-specific overexpression of NCOATGK, splice variant of O-GlcNAcase, induces skeletal muscle atrophy.American journal of physiology. Cell physiology · 2011Article
- Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases.Chemistry & biology · 2010Article
- Hexosamine flux, the O-GlcNAc modification, and the development of insulin resistance in adipocytes.Molecular and cellular endocrinology · 2010Review
- The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine.Biochimica et biophysica acta · 2010Review
- O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress.Biochimica et biophysica acta · 2010Review
- Increased O-GlcNAc causes disrupted lens fiber cell differentiation and cataracts.Biochemical and biophysical research communications · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Mechanisms controlling nuclear hormone receptors are a central question to mammalian developmental and disease processes. Herein, we show that a subtle increase in O-GlcNAc levels inhibits activation of nuclear hormone receptors. In vivo, increased levels of O-GlcNAc impair estrogen receptor activation and cause a decrease in mammary ductal side-branching morphogenesis associated with loss of progesterone receptors. Increased O-GlcNAc levels suppress transcriptional expression of coactivators and of the nuclear hormone receptors themselves. Surprisingly, increased O-GlcNAc levels are also associated with increased transcription of genes encoding corepressor proteins NCoR and SMRT. The association of the enzyme O-GlcNAc transferase with these corepressors contributes to specific regulation of nuclear hormone receptors by O-GlcNAc. Overall, transcriptional inhibition is related to the integrated effect of O-GlcNAc by direct modification of critical elements of the transcriptome and indirectly through O-GlcNAc modification of the proteasome.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.