ArticleJournal of neurovirology2006
Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome.
Article in Journal of neurovirology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
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- Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2DFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Central nervous system-specific consequences of simian immunodeficiency virus Gag escape from major histocompatibility complex class I-mediated control.Journal of neurovirology · 2016Article
- Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Compartmentalized intrathecal immunoglobulin synthesis during HIV infection - a model of chronic CNS inflammation?Journal of neuroimmunology · 2015Review
- Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered.Current HIV/AIDS reports · 2015Review
- Article
- Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition.Mediators of inflammation · 2015Review
- CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system.The Journal of infectious diseases · 2015Article
- Gene expression profiles and protein-protein interaction network analysis in AIDS patients with HIV-associated encephalitis and dementia.HIV/AIDS (Auckland, N.Z.) · 2015Article
- Human endogenous retroviruses and the nervous system.Handbook of clinical neurology · 2014Review
- Innate immune responses to HIV infection in the central nervous system.Immunologic research · 2013Review
- Neurologic complications of HIV-1 infection and its treatment in the era of antiretroviral therapy.Continuum (Minneapolis, Minn.) · 2012Review
- Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.PloS one · 2012Article
- Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier.Neuroimmunomodulation · 2012Review
- Neurologic consequences of the immune reconstitution inflammatory syndrome (IRIS).Current neurology and neuroscience reports · 2010Review
- Macrophages in Alzheimer's disease: the blood-borne identity.Journal of neural transmission (Vienna, Austria : 1996) · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CD8+ T cells infiltrate brains with human immunodeficiency virus type-1 (HIV-1) encephalitis (HIVE) and related animal models; their perineuronal localization suggests cytotoxic T cell (CTL)-mediated neuronal killing. Because CTLs have not been identified in acquired immunodeficiency syndrome (AIDS) brains, the authors identified their cytotoxic granules in autopsy AIDS brains with HIVE and without HIVE (HIVnE) plus controls (7 to 13 cases/group) and determined gene expression profiles of CTL-associated genes in a separate series of cases. CD3+ and CD8+ T cells were significantly increased (P < .01) in perivascular spaces and inflammatory nodules in HIVE but were rare or absent in brain parenchyma in HIVnE and control brains. Eight HIVE brains contained granzyme B+ T cells and five contained perforin+ T cells. Their T-cell origin was confirmed by colocalization of CD8 and granzyme B in the same cell and the absence of CD56+ natural killer cells. The CTLs directly contacted with neurons, as the authors showed previously for CD3+ and CD8+ T cells. CTLs were rare or absent in HIV nonencephalitis (HIVnE) and controls. Granzyme B and H precursor gene expression was up-regulated and interleukin (IL)-12A precursor, a maturation factor for natural killer cells and CTLs, was down-regulated in HIVE versus HIVnE brain. This study demonstrates, for the first time, CTLs in HIVE and shows that parenchymal T cells and CTLs are sensitive biomarkers for HIVE. Consequently, CD8+ T cells and CTLs could mediate brain injury in HIVE and may represent an important biomarker for productive brain infection by HIV-1.
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Registered trials
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