ReviewEnvironmental health perspectives2006
Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Review in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- A meta-analysis of occupational trichloroethylene exposure and liver cancer.International archives of occupational and environmental health · 2007Pooled it
- Elucidating the Mechanisms of Trichloroethylene-Induced Kidney Cancer: Network Toxicology, Molecular Docking, and In Vitro Validation.Journal of biochemical and molecular toxicology · 2026Article
- Trichloroethylene Exposure and Parkinson's Disease: Environmental Risk, Metabolic Pathways, and Mechanistic Insights.Molecular neurobiology · 2025Review
- Article
- Review
- Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains.Toxicology · 2018Article
- Non‑infective occupational risk factors for hepatocellular carcinoma: A review (Review).Molecular medicine reports · 2017Review
- Trichloroethylene-induced hypersensitivity dermatitis was associated with hepatic metabolic enzyme genes and immune-related genes.Toxicology research · 2016Article
- DCA promotes progression of neuroblastoma tumors in nude mice.American journal of cancer research · 2015Article
- Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice.Toxicology mechanisms and methods · 2014Article
- Human health effects of trichloroethylene: key findings and scientific issues.Environmental health perspectives · 2013Review
- Risk of hepatocellular carcinoma in workers exposed to chemicals.Hepatitis monthly · 2012Article
- Article
- Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant.International journal of occupational medicine and environmental health · 2011Article
- Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats.International journal of hepatology · 2011Article
- Biological Basis of Differential Susceptibility to Hepatocarcinogenesis among Mouse Strains.Journal of toxicologic pathology · 2009Article
- Genetic signature for human risk assessment: lessons from trichloroethylene.Environmental and molecular mutagenesis · 2009Review
- Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.Biochemical pharmacology · 2008Article
- Issues in the pharmacokinetics of trichloroethylene and its metabolites.Environmental health perspectives · 2006Review
- Trichloroethylene cancer epidemiology: a consideration of select issues.Environmental health perspectives · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE metabolites may be responsible for these effects, the key events involved in their modes of action (MOAs) , and the relevance of these MOAs to humans. In this article, which is part of a mini-monograph on key issues in the health risk assessment of TCE, we present a review of recently published scientific literature examining the effects of TCE metabolites in the context of the preceding questions. Studies of the TCE metabolites dichloroacetic acid (DCA) , trichloroacetic acid (TCA) , and chloral hydrate suggest that both DCA and TCA are involved in TCE-induced liver tumorigenesis and that many DCA effects are consistent with conditions that increase the risk of liver cancer in humans. Studies of S-(1,2-dichlorovinyl) -l-cysteine have revealed a number of different possible cell signaling effects that may be related to kidney tumorigenesis at lower concentrations than those leading to cytotoxicity. Recent studies of trichloroethanol exploring an alternative hypothesis for kidney tumorigenesis have failed to establish the formation of formate as a key event for TCE-induced kidney tumors. Overall, although MOAs and key events for TCE-induced liver and kidney tumors have yet to be definitively established, these results support the likelihood that toxicity is due to multiple metabolites through several MOAs, none of which appear to be irrelevant to humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.