ArticleEnvironmental health perspectives2006
Reproductive hormone levels in men exposed to persistent organohalogen pollutants: a study of inuit and three European cohorts.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Environmental and occupational pesticide exposure and human sperm parameters: a systematic review.Toxicology · 2013Pooled it
- Establishing the Mechanisms Involved in the Environmental Exposure to Polychlorinated Biphenyls (PCBs) in the Risk of Male Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Persistent organic pollutants and endogenous sex-related hormones in Hispanic/Latino adults: The Hispanic Community health study/study of Latinos (HCHS/SOL).Environmental research · 2025Article
- Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.Frontiers in endocrinology · 2021Review
- Multiple organochlorine pesticide exposures and measures of sex steroid hormones in adult males: Cross-sectional findings from the 1999-2004 National Health and Nutrition Examination Survey.International journal of hygiene and environmental health · 2021Article
- Article
- The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery.Obesity surgery · 2020Article
- Reproductive Function in a Population of Young Faroese Men with Elevated Exposure to Polychlorinated Biphenyls (PCBs) and Perfluorinated Alkylate Substances (PFAS).International journal of environmental research and public health · 2018Article
- Effects of pesticide exposure on reproductivity of male groundnut farmers in Kyauk Kan village, Nyaung-U, Mandalay region, Myanmar.Risk management and healthcare policy · 2018Article
- Health effects associated with measured levels of contaminants in the Arctic.International journal of circumpolar health · 2016Article
- Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls.Environmental research · 2015Article
- Association between environmental contaminants and health outcomes in indigenous populations of the Circumpolar North.International journal of circumpolar health · 2014Review
- Environmental mercury exposure, semen quality and reproductive hormones in Greenlandic Inuit and European men: a cross-sectional study.Asian journal of andrology · 2013Article
- Persistent organochlorine pollutants with endocrine activity and blood steroid hormone levels in middle-aged men.PloS one · 2013Article
- Serum concentrations of p, p'-DDE, HCB, PCBs and reproductive hormones among men of reproductive age.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.Environmental health : a global access science source · 2012Article
- The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity.Journal of assisted reproduction and genetics · 2011Article
- Towards integration of environmental and health impact assessments for wild capture fishing and farmed fish with particular reference to public health and occupational health dimensions.International journal of environmental research and public health · 2008Review
- Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.Environmental health perspectives · 2008Review
- Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations.Environmental health perspectives · 2007Article
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePersistent organohalogen pollutant (POP) exposure may have a negative impact on reproductive function. The objective of this study was to assess the impact of POP exposure on the male hypothalamo-pituitary-gonadal axis.
participantsParticipants included 184 Swedish fishermen and spouses of pregnant women from Greenland (n = 258), Warsaw, Poland (n = 113) , and Kharkiv, Ukraine (n = 194). EVALUATIONS/MEASUREMENTS: Serum levels of 2,2,4,4,5,5-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p -DDE) were determined in the four populations, showing different exposure patterns: Swedish fishermen, high CB-153/low p,p -DDE; Greenland, high CB-153/high p,p -DDE; Warsaw, low CB-153/moderate p,p -DDE; Kharkiv, low CB-153/high p,p -DDE. Serum was also analyzed for testosterone, estradiol, sex hormone-binding globulin (SHBG) , inhibin B, luteinizing hormone (LH) , and follicle-stimulating hormone (FSH) . Free testosterone levels were calculated based on testosterone and SHBG.
resultsWe found significant center-to-center variations in the associations between exposure and the outcomes. The most pronounced effects were observed in Kharkiv, where statistically significant positive associations were found between the levels of both CB-153 and p,p -DDE and SHBG, as well as LH. In Greenland, there was a positive association between CB-153 exposure and LH. In the pooled data set from all four centers, there was positive association between p,p -DDE and FSH levels [beta = 1.1 IU/L; 95% confidence interval (CI), 1.0-1.1 IU/L]. The association between CB-153 levels and SHBG was of borderline statistical significance (beta = 0.90 nmol/L; 95% CI, -0.04 to 1.9 nmol/L).
conclusionsGonadotropin levels and SHBG seem to be affected by POP exposure, but the pattern of endocrine response is the subject of considerable geographic variation.
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