Evidence map›Paper›PMID 16965702›Full record

ArticleEmerging infectious diseases2006

Antibody response to Pneumocystis jirovecii major surface glycoprotein.

Kieran R Daly, Laurence Huang, Alison Morris, Judy Koch, Kristina Crothers, Linda Levin, Shary Eiser, Supriya Satwah, Patricia Zucchi, Peter D Walzer

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Advances in pathogen detection ofInfectious medicine · 2025
    Review
  2. Pathogenic microorganism detection in AIDS patients using bronchoalveolar lavage fluid.International journal of clinical and experimental pathology · 2020
    Article
  3. Review
  4. The Interaction ofJournal of immunology (Baltimore, Md. : 1950) · 2017
    Article
  5. Article
  6. Current medical mycology · 2015
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Seroepidemiological study of Pneumocystis jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2010
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008
    Article
  19. Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kieran R DalyResearch Service 151, Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA.
Laurence Huang
Alison Morris
Judy Koch
Kristina Crothers
Linda Levin
Shary Eiser
Supriya Satwah
Patricia Zucchi
Peter D Walzer
University of New Haven · USUniversity of Southern California · USUniversity of Pavia · ITVeterans Health Administration · US

Funding

Epidemiology and Significance of P carinii ColonizationK23HL072837 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MORRIS, ALISON · 2003 to 2007
$662k
Molecular Epidemiology of Human P. carinii PneumoniaK23HL072117 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2003 to 2006
$486k
NCRR NIH HHS K12 RR 01175584-01NHLBI NIH HHS K23 HL 072117NHLBI NIH HHS K23 HL072117NHLBI NIH HHS K23 HL 072837NHLBI NIH HHS K23 HL072837NIAID NIH HHS F33 AI 06527NIAID NIH HHS N01 AI025467NIAID NIH HHS R01 AI 06492NIAID NIH HHS R03 AI 570636PHS HHS U01 A1 25467
6 · The paper itself

Abstract

We conducted a prospective pilot study of the serologic responses to overlapping recombinant fragments of the Pneumocystis jirovecii major surface glycoprotein (Msg) in HIV-infected patients with pneumonia due to P. jirovecii and other causes. Similar baseline geometric mean antibody levels to the fragments measured by an ELISA were found in both groups. Serum antibodies to MsgC in P. jirovecii patients rose to a peak level 3-4 weeks (p<0.001) after recovery from pneumocystosis; baseline CD4+ count > or =50 cells/microL and first episode of pneumocystosis were the principal host factors associated with this rise (both p<0.001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAntibodies, FungalEnzyme-Linked Immunosorbent AssayFemaleFungal ProteinsHIV InfectionsHumansMaleMembrane GlycoproteinsMiddle AgedPneumocystis cariniiPneumonia, PneumocystisAntibodies, FungalFungal ProteinsGPA protein, Pneumocystis carinii sp.Membrane Glycoproteins

Identifiers

PMID16965702
PMCPMC3291227
OpenAlexW2142777498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.