ArticlePLoS genetics2006
Genome-wide hierarchy of replication origin usage in Saccharomyces cerevisiae.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Dynamics of DNA replication in a eukaryotic cell.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transcription-dependent regulation of replication dynamics modulates genome stability.Nature structural & molecular biology · 2019Article
- Article
- High Throughput Analyses of Budding Yeast ARSs Reveal New DNA Elements Capable of Conferring Centromere-Independent Plasmid Propagation.G3 (Bethesda, Md.) · 2016Article
- Post-licensing Specification of Eukaryotic Replication Origins by Facilitated Mcm2-7 Sliding along DNA.Molecular cell · 2015Article
- Genome-wide replication landscape of Candida glabrata.BMC biology · 2015Article
- An autonomously replicating sequence for use in a wide range of budding yeasts.FEMS yeast research · 2014Article
- High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.Genome research · 2013Article
- A Link between ORC-origin binding mechanisms and origin activation time revealed in budding yeast.PLoS genetics · 2013Article
- Novel features of ARS selection in budding yeast Lachancea kluyveri.BMC genomics · 2011Article
- Initiation of DNA replication: functional and evolutionary aspects.Annals of botany · 2011Review
- Article
- Relicensing of transcriptionally inactivated replication origins in budding yeast.The Journal of biological chemistry · 2010Article
- Mathematical modelling of whole chromosome replication.Nucleic acids research · 2010Article
- The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin.Genes & development · 2010Article
- A comprehensive genome-wide map of autonomously replicating sequences in a naive genome.PLoS genetics · 2010Article
- Alternative mechanisms for coordinating polymerase alpha and MCM helicase.Molecular and cellular biology · 2010Article
- The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication.PLoS genetics · 2009Article
- A model for the spatiotemporal organization of DNA replication in Saccharomyces cerevisiae.Molecular genetics and genomics : MGG · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Replication origins in a genome are inherently different in their base sequence and in their response to temporal and cell cycle regulation signals for DNA replication. To investigate the chromosomal determinants that influence the efficiency of initiation of DNA replication genome-wide, we made use of a reverse strategy originally used for the isolation of replication initiation mutants in Saccharomyces cerevisiae. In yeast, replication origins isolated from chromosomes support the autonomous replication of plasmids. These replication origins, whether in the context of a chromosome or a plasmid, will initiate efficiently in wild-type cells but show a dramatically contrasted efficiency of activation in mutants defective in the early steps of replication initiation. Serial passages of a genomic library of autonomously replicating sequences (ARSs) in such a mutant allowed us to select for constitutively active ARSs. We found a hierarchy of preferential initiation of ARSs that correlates with local transcription patterns. This preferential usage is enhanced in mutants defective in the assembly of the prereplication complex (pre-RC) but not in mutants defective in the activation of the pre-RC. Our findings are consistent with an interference of local transcription with the assembly of the pre-RC at a majority of replication origins.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.