ArticleBiophysical journal1990
Glutamate receptor-channel gating. Maximum likelihood analysis of gigaohm seal recordings from locust muscle.
Article in Biophysical journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The effects of non-identifiability on testing for detailed balance in aggregated Markov models for ion-channel gating.Biophysical journal · 2000Article
- Evaluation of the number of agonist molecules needed to activate a ligand-gated channel from the current rising phase.Biophysical journal · 2000Article
- Activation kinetics of glutamate receptor channels from wild-type Drosophila muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Potassium channels of adult locust (Schistocerca gregaria) muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Ryanoids change the permeability of potassium channels of locust (Schistocerca gregaria) muscle.Pflugers Archiv : European journal of physiology · 1996Article
- Gating kinetics of the quisqualate-sensitive glutamate receptor of locust muscle studied using agonist concentration jumps and computer simulations.Biophysical journal · 1993Article
- Single ion channel models incorporating aggregation and time interval omission.Biophysical journal · 1993Article
- A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating.The Journal of physiology · 1993Article
- Accounting for the Ca(2+)-dependent kinetics of single large-conductance Ca(2+)-activated K+ channels in rat skeletal muscle.The Journal of physiology · 1991Article
- Calcium-activated potassium channels: regulation by calcium.Journal of bioenergetics and biomembranes · 1991Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gigaohm recordings have been made from glutamate receptor channels in excised, outside-out patches of collagenase-treated locust muscle membrane. The channels in the excised patches exhibit the kinetic state switching first seen in megaohm recordings from intact muscle fibers. Analysis of channel dwell time distributions reveals that the gating mechanism contains at least four open states and at least four closed states. Dwell time autocorrelation function analysis shows that there are at least three gateways linking the open states of the channel with the closed states. A maximum likelihood procedure has been used to fit six different gating models to the single channel data. Of these models, a cooperative model yields the best fit, and accurately predicts most features of the observed channel gating kinetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.