ArticleOncogene2007
Characterizing a rat Brca2 knockout model.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Causal Relationship Between Cataracts and Gastrointestinal Diseases: A Two-Sample Mendelian Randomization Study.Translational vision science & technology · 2025Article
- Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats.Scientific reports · 2025Article
- Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes.Journal of biomedical science · 2020Review
- The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.Developmental biology · 2017Article
- Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours.Veterinary research communications · 2014Article
- Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis.Carcinogenesis · 2012Article
- Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.The American journal of pathology · 2011Article
- Systematic generation of in vivo G protein-coupled receptor mutants in the rat.The pharmacogenomics journal · 2011Article
- Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.PLoS genetics · 2011Article
- Homologs of breast cancer genes in plants.Frontiers in plant science · 2011Article
- Rat traps: filling the toolbox for manipulating the rat genome.Genome biology · 2010Review
- Morphological and extracellular matrix changes following vocal fold injury in mice.Cells, tissues, organs · 2010Article
- p63 and p73 transcriptionally regulate genes involved in DNA repair.PLoS genetics · 2009Article
- Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.The Journal of cell biology · 2008Article
- Mammary cancer susceptibility: human genes and rodent models.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Evidence exists that BRCA2 carriers may have an elevated risk of breast, ovarian, colon, prostate, and pancreatic cancer. In general, carriers are defined as individuals with protein truncating mutations within the BRCA2 gene. Many Brca2 knockout lines have been produced and characterized in the mouse. We previously produced a rat Brca2 knockout strain in which there is a nonsense mutation in exon 11 between BRC repeats 2 and 3, and a truncated protein is produced. Interestingly, while such a mutation in homozygous mice would lead to limited survival of approximately 3 months, the Brca2-/- rats are 100% viable and the vast majority live to over 1 year of age. Brca2-/- rats show a phenotype of growth inhibition and sterility in both sexes. Aspermatogenesis in the Brca2-/- rats is due to a failure of homologous chromosome synapsis. Long-term phenotypes include underdeveloped mammary glands, cataract formation and lifespan shortening due to the development of tumors and cancers in multiple organs. The establishment of the rat Brca2 knockout model provides a means to study the role of Brca2 in increasing cancer susceptibility and inducing a novel ocular phenotype not previously associated with this gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.