ArticleGenome research2006
Large-scale intron conservation and order-of-magnitude variation in intron loss/gain rates in apicomplexan evolution.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Intron losses and gains in the nematodes.Biology direct · 2022Article
- Genome microsatellite diversity within the Apicomplexa phylum.Molecular genetics and genomics : MGG · 2016Article
- Evaluation of the mechanisms of intron loss and gain in the social amoebae Dictyostelium.BMC evolutionary biology · 2015Article
- Recombination of chl-fus gene (Plastid Origin) downstream of hop: a locus of chromosomal instability.BMC genomics · 2015Article
- Imprecise intron losses are less frequent than precise intron losses but are not rare in plants.Biology direct · 2015Article
- Homopolymer tract organization in the human malarial parasite Plasmodium falciparum and related Apicomplexan parasites.BMC genomics · 2014Article
- The Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems.Nucleic acids research · 2014Article
- Origin of spliceosomal introns and alternative splicing.Cold Spring Harbor perspectives in biology · 2014Article
- Frequency of intron loss correlates with processed pseudogene abundance: a novel strategy to test the reverse transcriptase model of intron loss.BMC biology · 2013Article
- Association of intron loss with high mutation rate in Arabidopsis: implications for genome size evolution.Genome biology and evolution · 2013Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Eimeria maxima phosphatidylinositol 4-phosphate 5-kinase: locus sequencing, characterization, and cross-phylum comparison.Parasitology research · 2011Article
- Evidence for retrogene origins of the prion gene family.PloS one · 2011Article
- Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures.Genome biology and evolution · 2011Article
- Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi.Journal of molecular evolution · 2010Article
- Malin: maximum likelihood analysis of intron evolution in eukaryotes.Bioinformatics (Oxford, England) · 2008Article
- Origins of human malaria: rare genomic changes and full mitochondrial genomes confirm the relationship of Plasmodium falciparum to other mammalian parasites but complicate the origins of Plasmodium vivax.Molecular biology and evolution · 2008Article
- Evidence against the energetic cost hypothesis for the short introns in highly expressed genes.BMC evolutionary biology · 2008Article
- Alternative splicing: a missing piece in the puzzle of intron gain.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Consistent and contrasting properties of lineage-specific genes in the apicomplexan parasites Plasmodium and Theileria.BMC evolutionary biology · 2008Article
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2 authors.
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Abstract
The age of modern introns and the evolutionary forces controlling intron loss and gain remain matters of much debate. In the case of the apicomplexan malaria parasite Plasmodium falciparum, previous studies have shown that while the positions of two thirds of P. falciparum introns are not shared with surveyed non-apicomplexans (leaving open the possibility that they were relatively recently gained), 99.1% are shared with Plasmodium yoelii, which diverged from P. falciparum at least 100 Mya. We show here that 60.6% of P. falciparum intron positions in conserved regions are shared with the distantly related apicomplexan Theileria parva, whereas only 18.2% of introns in the more intron-rich T. parva are shared with P. falciparum. Comparison of 3305 pairs of orthologous genes between T. parva and Theileria annulata showed that 7089/7111 (99.7%) introns in conserved regions are shared between species. These levels of conservation imply significant differences in rates of intron loss and gain through apicomplexan history. Because transposable elements (TEs) and/or (often TE-encoded) reverse transcriptase are implicated in models of intron loss and gain, the observed low rates of intron loss and gain in recent Plasmodium and Theileria evolution are consistent with the lack of known TE in those groups. We suggest that intron loss/gain in some eukaryotic lineages may be concentrated in relatively short episodes coincident with occasional TE invasions.
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