ArticleGenome research2006
Genomic organization of the Drosophila telomere retrotransposable elements.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 90 citations in OpenAlex.
- Satellite DNAs rising from the transposon graveyards.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Review
- Transcriptional coupling of telomeric retrotransposons with the cell cycle.Science advances · 2025Article
- Long non-coding RNAs involved inNAR genomics and bioinformatics · 2024Article
- Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers.Nucleic acids research · 2022Article
- Review
- The nanoCUT&RUN technique visualizes telomeric chromatin in Drosophila.PLoS genetics · 2022Article
- Genetic and Epigenetic Inheritance at Telomeres.Epigenomes · 2022Review
- Review
- Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.PLoS genetics · 2021Article
- Rapid evolution at the Drosophila telomere: transposable element dynamics at an intrinsically unstable locus.Genetics · 2021Article
- Potential Antiaging Effects of DLBS1649, aJournal of experimental pharmacology · 2021Article
- Evidence for premature aging in a Drosophila model of Werner syndrome.Experimental gerontology · 2019Article
- Diversification and collapse of a telomere elongation mechanism.Genome research · 2019Article
- Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline.Epigenetics & chromatin · 2018Article
- Double insertion of transposable elements provides a substrate for the evolution of satellite DNA.Genome research · 2018Article
- The case for not masking away repetitive DNA.Mobile DNA · 2018Article
- Article
- Natural variation of piRNA expression affects immunity to transposable elements.PLoS genetics · 2017Article
- Transposable elements inMobile genetic elements · 2017Review
- Unique transposon landscapes are pervasive across Drosophila melanogaster genomes.Nucleic acids research · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The emerging sequence of the heterochromatic portion of the Drosophila melanogaster genome, with the most recent update of euchromatic sequence, gives the first genome-wide view of the chromosomal distribution of the telomeric retrotransposons, HeT-A, TART, and Tahre. As expected, these elements are entirely excluded from euchromatin, although sequence fragments of HeT-A and TART 3 untranslated regions are found in nontelomeric heterochromatin on the Y chromosome. The proximal ends of HeT-A/TART arrays appear to be a transition zone because only here do other transposable elements mix in the array. The sharp distinction between the distribution of telomeric elements and that of other transposable elements suggests that chromatin structure is important in telomere element localization. Measurements reported here show (1) D. melanogaster telomeres are very long, in the size range reported for inbred mouse strains (averaging 46 kb per chromosome end in Drosophila stock 2057). As in organisms with telomerase, their length varies depending on genotype. There is also slight under-replication in polytene nuclei. (2) Surprisingly, the relationship between the number of HeT-A and TART elements is not stochastic but is strongly correlated across stocks, supporting the idea that the two elements are interdependent. Although currently assembled portions of the HeT-A/TART arrays are from the most-proximal part of long arrays, approximately 61% of the total HeT-A sequence in these regions consists of intact, potentially active elements with little evidence of sequence decay, making it likely that the content of the telomere arrays turns over more extensively than has been thought.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.