ArticlePlant physiology2006
Pathogen-induced Arabidopsis WRKY7 is a transcriptional repressor and enhances plant susceptibility to Pseudomonas syringae.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed, 182 citations in OpenAlex.
- Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant-Pathogen Interface.Plant biotechnology journal · 2026Review
- Integration of Spatiotemporal Multi-Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome-Mediated Stress Adaptation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Functional divergence of BnaWRKY7 homologs drives phytosterol variations in polyploid Brassica napus.Journal of advanced research · 2026Article
- Functional characterization of FvCAMTA1in salt stress response ofFrontiers in plant science · 2025Article
- The Negative Regulators of the Basal Defence WRKY7, WRKY11 and WRKY17 Modulate the Jasmonic Acid Pathway and an Alternative Splicing Regulatory Network in Response to Pseudomonas syringae in Arabidopsis thaliana.Molecular plant pathology · 2024Article
- A critical role of a plant-specific TFIIB-related protein, BRP1, in salicylic acid-mediated immune response.Frontiers in plant science · 2024Article
- A 4D Proteome Investigation of the Potential Mechanisms of SA in Triggering Resistance in Kiwifruit toInternational journal of molecular sciences · 2023Article
- SlWRKY16 and SlWRKY31 of tomato, negative regulators of plant defense, involved in susceptibility activation following root-knot nematode Meloidogyne javanica infection.Scientific reports · 2023Article
- Genome-Wide Identification of Sweet Orange WRKY Transcription Factors and Analysis of Their Expression in Response to Infection byCurrent issues in molecular biology · 2023Article
- Heterologous Expression ofInternational journal of molecular sciences · 2022Article
- Analyses of Botrytis cinerea-responsive LrWRKY genes from Lilium regale reveal distinct roles of two LrWRKY transcription factors in mediating responses to B. cinerea.Plant cell reports · 2022Article
- Characterization of the WRKY gene family in Akebia trifoliata and their response to Colletotrichum acutatum.BMC plant biology · 2022Article
- Global transcriptome and targeted metabolite analyses of roots reveal different defence mechanisms againstFrontiers in plant science · 2022Article
- The THO/TREX Complex Active in Alternative Splicing Mediates Plant Responses to Salicylic Acid and Jasmonic Acid.International journal of molecular sciences · 2021Article
- A salicylic acid inducible mulberry WRKY transcription factor, MiWRKY53 is involved in plant defence response.Plant cell reports · 2021Article
- Article
- Genome-wide identification and expression analysis of the WRKY transcription factor family in flax (Linum usitatissimum L.).BMC genomics · 2021Article
- Overexpression of ZmWRKY65 transcription factor from maize confers stress resistances in transgenic Arabidopsis.Scientific reports · 2021Article
- LlWRKY39 is involved in thermotolerance by activating LlMBF1c and interacting with LlCaM3 in lily (Lilium longiflorum).Horticulture research · 2021Article
- CsWRKY25 Improves Resistance of Citrus Fruit toFrontiers in plant science · 2021Article
21 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis (Arabidopsis thaliana) WRKY7 gene is induced by pathogen infection and salicylic acid (SA) treatment and may therefore play a role in plant defense responses. Here, we show that WRKY7 is localized in the nucleus, recognizes DNA molecules with the W-box (TTGAC) elements, and functions as a transcriptional repressor in plant cells. To study its biological functions directly, we have characterized both loss-of-function T-DNA insertion and RNAi mutants and gain-of-function transgenic overexpression plants for WRKY7 in Arabidopsis. The T-DNA insertion and RNAi mutant plants displayed enhanced resistance to a virulent strain of the bacterial pathogen Pseudomonas syringae as measured by significant decrease in both bacterial growth and symptom development as compared to those in wild-type plants. The enhanced resistance in the loss-of-function mutants was associated with increased induction of SA-regulated Pathogenesis-Related 1 (PR1) by the bacterial pathogen. Transgenic plants that constitutively overexpress WRKY7 have altered leaf growth and morphology strikingly similar to those observed in the previously isolated eds8 mutant plants. Like eds8 mutant plants, WRKY7-overexpressing plants supported more growth of P. syringae and developed more severe disease symptoms than wild-type plants. The enhanced susceptibility of both the WRKY7-overexpressing plants and the eds8 mutant correlated with reduced expression of defense-related genes, including PR1, but significantly increased accumulation of SA after pathogen infection, probably due to reduced negative feedback of SA synthesis. Thus, pathogen-induced WRKY7 transcription factor play a negative role in defense responses to P. syringae.
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